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8/25/2014 2:47:00 PM | Browse: 982 | Download: 880
Publication Name World Journal of Gastroenterology
Manuscript ID 4179
Country Germany
Received
2013-06-19 09:40
Peer-Review Started
2013-06-20 09:41
To Make the First Decision
2013-10-14 21:22
Return for Revision
2013-10-19 15:44
Revised
Second Decision
2014-01-20 18:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:12
Articles in Press
2014-05-23 10:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-07-21 12:08
Publish the Manuscript Online
2014-08-07 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Autobiography
Article Title Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells
Manuscript Source Invited Manuscript
All Author List Matilde Spampatti, George Vlotides, Gerald Spöttl, Julian Maurer, Burkhard Göke and Christoph J Auernhammer
Funding Agency and Grant Number
Corresponding Author Dr. Christoph J Auernhammer, Department of Internal Medicine Ⅱ, University-Hospital Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), Ludwig-Maximilians-University of Munich, Marchioninistr 15, 81377 Munich, Germany. cauernha@med.uni-muenchen.de
Key Words Neuroendocrine tumors; Aspirin; Cell Viability; Mammalian target of rapamycin protein
Core Tip We evaluated the effects of aspirin on pancreatic (BON1), bronchopulmonary (NCI-H727) and midgut (GOT1) neuroendocrine tumor cell lines and demonstrated that aspirin has potent antitumor properties in vitro. Aspirin caused a dose-dependent reduction of cell viability/cell proliferation, the inhibition of targets downstream of mammalian target of rapamycin and the (compensatory) activation of the AKT and extracellular signal-regulated kinase signaling pathways. Treatment of BON1 and NCI-H727 cells with aspirin reduced the entry of these cells into the S phase of the cell cycle, and this effect was associated with the induction of p21 and reduced cyclin-dependent kinase 4 and cyclin D3 expression.
Publish Date 2014-08-07 10:34
Citation Spampatti M, Vlotides G, Spöttl G, Maurer J, Göke B, Auernhammer CJ. Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells. World J Gastroenterol 2014; 20(29): 10038-10049
URL http://www.wjgnet.com/1007-9327/full/v20/i29/10038.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i29.10038
Full Article (PDF) WJG-20-10038.pdf
Full Article (Word) WJG-20-10038.doc
Manuscript File 4179-Review.docx
Answering Reviewers 4179-Answering reviewers.pdf
Copyright License Agreement 4179-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4179-Language certificate.pdf
Peer-review Report 4179-Peer review(s).pdf
Scientific Editor Work List 4179-Scientific editor work list.doc