Publication Name	World Journal of Orthopedics
Manuscript ID	41828
Country	Italy

Received	2018-08-28 03:20
Peer-Review Started	2018-08-28 11:49
To Make the First Decision	2018-10-08 07:39
Return for Revision	2018-10-09 01:06
Revised	2018-10-11 16:31
Second Decision	2018-10-17 07:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-10-18 04:17
Articles in Press	2018-10-18 04:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-10-31 19:39
Typeset the Manuscript	2018-11-10 10:30
Publish the Manuscript Online	2018-11-15 10:02

ISSN	2218-5836 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Recently highlighted nutraceuticals for preventive management of osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Silvia Ravalli, Marta Anna Szychlinska, Rosalia Maria Leonardi and Giuseppe Musumeci
ORCID	Author(s) ORCID Number Silvia Ravalli http://orcid.org/0000-0003-3358-1086 Marta Anna Szychlinska http://orcid.org/0000-0001-5281-1516 Rosalia Maria Leonardi http://orcid.org/0000-0002-9433-9528 Giuseppe Musumeci http://orcid.org/0000-0002-8260-8890
Funding Agency and Grant Number
Corresponding Author	Giuseppe Musumeci, BSc, MSc, PhD, Associate Professor, Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology section, School of Medicine, University of Catania, Via S. Sofia 87, Catania 95123, Italy. g.musumeci@unict.it
Key Words	Osteoarthritis; Nutraceuticals; Prevention; Diet; Inflammation; Oxidative stress
Core Tip	Osteoarthritis involves the significant expression of inflammatory cytokines, matrix proteins and proteolytic enzymes. For this reason, anti-inflammatory molecules play a major role in controlling the adverse effects of cartilage homeostatic balance loss. Olive oil, olive leaf extract, curcumin and sanguinarine have been studied as supplements with anti-inflammatory properties. Moreover, chondrocytes undergo senescence and cell death in the presence of oxidative stress. Potential targets involved in this mechanism are counteracted by anti-oxidant molecules like vitamin D and carnosic acid.
Publish Date	2018-11-15 10:02
Citation	Ravalli S, Szychlinska MA, Leonardi RM, Musumeci G. Recently highlighted nutraceuticals for preventive management of osteoarthritis. World J Orthop 2018; 9(11): 255-261
URL	http://www.wjgnet.com/2218-5836/full/v9/i11/255.htm
DOI	http://dx.doi.org/10.5312/wjo.v9.i11.255

Full Article (PDF)	WJO-9-255.pdf
Full Article (Word)	WJO-9-255.doc
Manuscript File	41828-Review.docx
Answering Reviewers	41828-Answering reviewers.pdf
Audio Core Tip	41828-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	41828-Conflict-of-interest statement.pdf
Copyright License Agreement	41828-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	41828-Language certificate.pdf
Peer-review Report	41828-Peer-review(s).pdf
Scientific Misconduct Check	41828-Scientific misconduct check.pdf
Scientific Editor Work List	41828-Scientific editor work list.pdf