| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Yan Xue, Xiu-Min Qin, Yong Liu, Jun Liang, Hua Lin, Xue-Min Xue, Shuang-Mei Zou, Mo-Yan Zhang, Bai-Hua Zhang, zhou-Guang Hui, Zi-Tong Zhao, Li-Qun Ren, Yue-Ming Zhang, Xiu-Yun Liu, Yan-Ling Yuan, Jian-Ming Ying, Shu-Geng Gao, Yong-Mei Song, Gui-Qi Wang, Sanford M Dawsey and Ning Lu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of the People’s Republic of China |
81402463 |
| CAMS Innovation Fund for Medical Sciences (CIFMS) |
2016-I2M-1-001 and 2016-I2M-3-005 |
| the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences |
2016ZX310178 and 2017PT32001 |
|
| Corresponding Author |
Ning Lu, MD, Chief Doctor, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. nlu03@126.com |
| Key Words |
Esophageal squamous cell carcinoma; Tumor recurrence; Lymph node negative esophageal cancer; Recurrence-free survival; Clinicopathological parameters |
| Core Tip |
Recurrences of pT1N0 esophageal squamous cell carcinoma (ESCC) after esophagectomy are usually metachronous regional lymph node or distant metastases. We analyzed 199 thoracic pT1N0 ESCC cases who underwent esophagectomy and thoracoabdominal two-field lymphadenectomy. Forty-seven (24%) patients had a recurrence during 3 to 178 (median, 33) mo. Upper thoracic tumor location, angiolymphatic invasion, and submucosal invasion thickness were independent predictors of tumor recurrence, and a nomogram for predicting recurrence-free survival with these three predictors was constructed. These results should be useful for designing optimal individual follow-up and therapy for patients with T1N0 ESCC. |
| Publish Date |
2018-12-07 03:57 |
| Citation |
Xue LY, Qin XM, Liu Y, Liang J, Lin H, Xue XM, Zou SM, Zhang MY, Zhang BH, Hui ZG, Zhao ZT, Ren LQ, Zhang YM, Liu XY, Yuan YL, Ying JM, Gao SG, Song YM, Wang GQ, Dawsey SM, Lu N. Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma. World J Gastroenterol 2018; 24(45): 5154-5166 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i45/5154.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i45.5154 |
