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Articles Published Processes
12/6/2018 1:35:45 PM | Browse: 984 | Download: 1102
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Received |
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2018-09-03 08:24 |
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Peer-Review Started |
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2018-09-03 12:14 |
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To Make the First Decision |
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2018-10-15 01:53 |
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Return for Revision |
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2018-10-15 03:23 |
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Revised |
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2018-10-26 12:12 |
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Second Decision |
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2018-11-14 09:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-11-15 02:43 |
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Articles in Press |
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2018-11-15 02:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-30 01:49 |
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Publish the Manuscript Online |
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2018-12-06 13:35 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Inflammation and de-differentiation in pancreatic carcinogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiro Seimiya, Motoyuki Otsuka, Takuma Iwata, Eri Tanaka, Tatsunori Suzuki, Kazuma Sekiba, Mari Yamagami, Rei Ishibashi and Kazuhiko Koike |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Program on Hepatitis from Japan Agency for Medical Research and Development, AMED |
JP18fk0210214 |
| Project for Cancer Research and Therapeutic Evolution (P-CREATE) from AMED |
JP19cm0106602 |
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| Corresponding Author |
Motoyuki Otsuka, MD, PhD, Assistant Professor, Doctor, Lecturer, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-8655, Japan. otsukamo-tky@umin.ac.jp |
| Key Words |
Pancreatitis; Inflammation; Organogenesis; Differentiation; Transcription factor; Pancreatic cancer |
| Core Tip |
Inflammation is involved in carcinogenesis by causing DNA damage. Recent studies show that carcinogenesis is promoted by reprogramming factors and by suppressing transcription factors related to acinar cell differentiation. Pancreatitis also shows such transcriptional changes, suggesting that epigenetic changes by several causes leading to the impaired differentiation may constitute an important framework for pancreatic carcinogenesis. New diagnostic, preventive and/or treatment strategies based on the findings described in this review are expected to be clinically applied in the near future. |
| Publish Date |
2018-12-06 13:35 |
| Citation |
Seimiya T, Otsuka M, Iwata T, Tanaka E, Suzuki T, Sekiba K, Yamagami M, Ishibashi R, Koike K. Inflammation and de-differentiation in pancreatic carcinogenesis. World J Clin Cases 2018; 6(15): 882-891 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i15/882.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i15.882 |
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