BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/27/2019 4:11:15 AM | Browse: 811 | Download: 1162
Publication Name World Journal of Gastroenterology
Manuscript ID 42334
Country/Territory China
Received
2018-09-28 01:25
Peer-Review Started
2018-09-28 09:32
To Make the First Decision
2018-10-24 02:09
Return for Revision
2018-10-26 08:19
Revised
2018-12-25 14:07
Second Decision
2018-12-27 10:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-28 05:11
Articles in Press
2018-12-28 05:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-01-09 10:50
Typeset the Manuscript
2019-02-26 07:42
Publish the Manuscript Online
2019-02-27 04:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Dbx2 performs a tumor-promoting function in hepatocellular carcinoma cell lines via regulating the Shh-Gli1 pathway
Manuscript Source Unsolicited Manuscript
All Author List Yan-Ting Hu, Bei-Fang Li, Peng-Jun Zhang, Di Wu, Yan-Yan Li, Zhong-Wu Li, Lin Shen, Jing Gao, Bin Dong and Xu Zhu
ORCID
Author(s) ORCID Number
Yan-Ting Hu http://orcid.org/0000-0002-9659-9227
Bei-Fang Li http://orcid.org/0000-0002-7391-2495
Peng-Jun Zhang http://orcid.org/0000-0003-3355-2306
Di Wu http://orcid.org/0000-0002-0419-6552
Yan-Yan Li http://orcid.org/0000-0003-3886-2178
Zhong-Wu Li http://orcid.org/0000-0001-7339-8759
Lin Shen http://orcid.org/0000-0003-3796-3129
Jing Gao http://orcid.org/0000-0002-1583-0221
Bin Dong http://orcid.org/0000-0002-3956-8408
Xu Zhu http://orcid.org/0000-0001-9983-5048
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81571781
Corresponding Author Xu Zhu, MD, PhD, Doctor, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital and Institute, No. 52, Fucheng Road, Haidian District, Beijing 100214, China. drzhuxu@163.com
Key Words Developing brain homeobox 2; Hepatocellular carcinoma; Sonic Hedgehog pathway; Expression; Tumor tissues
Core Tip Core tip: Developing brain homeobox 2 (Dbx2) plays an important role in cell differentiation and is frequently upregulated in tumor tissues, while its function in hepatocellular carcinoma (HCC) has not been reported. Our results indicate that Dbx2 significantly upregulated in HCC tissues and strongly correlated with tumor size. Subsequently, both gain and loss of function assays indicated that Dbx2 promoted HCC migration, invasion and proliferation by facilitating the transition from G1 to S, attenuating apoptosis in vitro and in vivo. Mechanistically, Dbx2 modulated sonic hedgehog (Shh) signaling by enhancing FTCH1 and GLi1 expression in HCC cells.
Publish Date 2019-02-27 04:11
Citation Hu YT, Li BF, Zhang PJ, Wu D, Li YY, Li ZW, Shen L, Dong B, Gao J, Zhu X. Dbx2 exhibits a tumor-promoting role in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling. World J Gastroenterol 2019; 25(8): 923-940
URL https://www.wjgnet.com/1007-9327/full/v25/i8/923.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i8.923
Full Article (PDF) WJG-25-923.pdf
Full Article (Word) WJG-25-923.docx
The ARRIVE Guidelines 42334-The ARRIVE guidelines.pdf
Manuscript File 42334-Review.docx
Answering Reviewers 42334-Answering reviewers.pdf
Audio Core Tip 42334-Audio core tip.MP3
Biostatistics Review Certificate 42334-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42334-Conflict-of-interest statement.pdf
Copyright License Agreement 42334-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42334-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 42334-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 42334-Institutional Review Board Approval Form or Document.pdf
Non-Native Speakers of English Editing Certificate 42334-Language certificate.pdf
Peer-review Report 42334-Peer-review(s).pdf
Scientific Misconduct Check 42334-Scientific misconduct check.pdf
Scientific Editor Work List 42334-Scientific editor work list.pdf