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12/7/2018 3:57:11 AM | Browse: 750 | Download: 1007
Publication Name World Journal of Gastroenterology
Manuscript ID 42515
Country/Territory China
Received
2018-09-27 01:18
Peer-Review Started
2018-09-27 06:02
To Make the First Decision
2018-10-11 08:42
Return for Revision
2018-10-14 05:57
Revised
2018-10-20 14:01
Second Decision
2018-11-09 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-09 18:03
Articles in Press
2018-11-09 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-15 03:08
Typeset the Manuscript
2018-12-06 03:26
Publish the Manuscript Online
2018-12-07 03:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages
Manuscript Source Unsolicited Manuscript
All Author List Ruo-Hong Liu, Yi Wen, Hong-Yu Sun, Chun-Yu Liu, Yu-Fan Zhang, Yi Yang, Qi-Lin Huang, Jia-Jia Tang, Can-Chen Huang and Li-Jun Tang
ORCID
Author(s) ORCID Number
Ruo-Hong Liu http://orcid.org/0000-0003-0885-8397
Yi Wen http://orcid.org/0000-0001-9801-0853
Hong-Yu Sun http://orcid.org/0000-0003-0000-0000
Chun-Yu Liu http://orcid.org/0000-0002-4768-0459
Yu-Fan Zhang http://orcid.org/0000-0002-3015-4962
Yi Yang http://orcid.org/0000-0002-0189-6246
Qi-Lin Huang http://orcid.org/0000-0002-0819-4829
Jia-Jia Tang http://orcid.org/0000-0001-6036-6133
Can-Chen Huang http://orcid.org/0000-0002-5598-4225
Li-Jun Tang http://orcid.org/0000-0001-6000-9515
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81772001
National Natural Science Foundation of China 8177071311
National Natural Science Foundation of China 81502696
National Clinical Key Subject of China 41792113
Technology Plan Program of Sichuan Provence 2015SZ0229
Technology Plan Program of Sichuan Provence 2018JY0041
Technology Plan Program of Sichuan Provence 18YYJC0442
Science and Technology development plan of Sichuan Province 2016YJ0023
Corresponding Author Li-Jun Tang, MD, PhD, Chief Doctor, Doctor, PLA Center of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, Chengdu Military General Hospital, No. 270 Tianhui Road, Rongdu Avenue, Jinniu, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com
Key Words Abdominal paracentesis drainage; Peritoneal macrophages; Polarization; Severe acute pancreatitis
Core Tip In the present study, we provided evidence for the first time that abdominal paracentesis drainage (APD) ameliorates inflammation in rats with severe acute pancreatitis (SAP) by regulating peritoneal macrophage M2 polarization. The important findings are that: (1) by removing pancreatitis-associated ascitic fluids, APD could improve the inflammatory environment of the peritoneal cavity; (2) the improved environment in the peritoneal cavity could polarize peritoneal macrophages towards the M2 phenotype; and (3) APD could promote M2 polarization of macrophages in the pancreas of SAP model rats. These findings provide new insights into the mechanisms underlying the effectiveness of APD, which may advance the clinical use of APD to benefit patients with SAP.
Publish Date 2018-12-07 03:57
Citation Liu RH, Wen Y, Sun HY, Liu CY, Zhang YF, Yang Y, Huang QL, Tang JJ, Huang CC, Tang LJ. Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages. World J Gastroenterol 2018; 24(45): 5131-5143
URL http://www.wjgnet.com/1007-9327/full/v24/i45/5131.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i45.5131
Full Article (PDF) WJG-24-5131.pdf
Full Article (Word) WJG-24-5131.doc
The ARRIVE Guidelines 42515-The ARRIVE guidelines.pdf
Manuscript File 42515-Review.docx
Answering Reviewers 42515-Answering reviewers.pdf
Audio Core Tip 42515-Audio core tip.m4a
Biostatistics Review Certificate 42515-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42515-Conflict-of-interest statement.pdf
Copyright License Agreement 42515-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42515-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 42515-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 42515-Institutional Review Board Approval Form or Document.jpeg
Non-Native Speakers of English Editing Certificate 42515-Language certificate.pdf
Peer-review Report 42515-Peer-review(s).pdf
Scientific Misconduct Check 42515-Scientific misconduct check.pdf
Scientific Editor Work List 42515-Scientific editor work list.pdf