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8/16/2019 12:41:28 AM | Browse: 685 | Download: 1357
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 42785
Country/Territory China
Received
2018-10-22 07:12
Peer-Review Started
2018-10-23 02:58
To Make the First Decision
2018-11-29 07:55
Return for Revision
2018-12-03 09:07
Revised
2019-01-23 03:14
Second Decision
2019-02-26 07:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-27 16:56
Articles in Press
2019-02-27 16:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-27 18:39
Typeset the Manuscript
2019-08-15 06:49
Publish the Manuscript Online
2019-08-16 00:41
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Si-Si Li, Wei-Liang Jiang, Wen-Qin Xiao, Kai Li, Ye-Fei Zhang, Xing-Ya Guo, Yi-Qi Dai, Qiu-Yan Zhao, Ming-Jie Jiang, Zhan-Jun Lu and Rong Wan
ORCID
Author(s) ORCID Number
Si-Si Li http://orcid.org/0000-0001-9375-4538
Wei-Liang Jiang http://orcid.org/0000-0002-0304-0847
Wen-Qin Xiao http://orcid.org/0000-0002-8621-6608
Kai Li http://orcid.org/0000-0001-6699-2290
Ye-Fei Zhang http://orcid.org/0000-0001-9800-9019
Xing-Ya Guo http://orcid.org/0000-0002-2644-5126
Yi-Qi Dai http://orcid.org/0000-0001-5802-2593
Qiu-Yan Zhao http://orcid.org/0000-0003-2724-9052
Ming-Jie Jiang http://orcid.org/0000-0001-8798-9904
Zhan-Jun Lu http://orcid.org/0000-0001-6881-5810
Rong Wan http://orcid.org/0000-0003-1824-7153
Funding Agency and Grant Number
Corresponding Author Rong Wan, PhD, Chief Doctor, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai 201620, China. doctorwanrong1970@126.com
Key Words Pancreatic neoplasms; Curcumin analog; Histone methyltransferase 2D; Therapeutic effects; Bioinformatics;
Core Tip We first report the anti-tumor effect of L48H37 in pancreatic cancer and ascertain that KMT2D deficiency contributed significantly to the therapeutic effect in part through the protein kinase RNA-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4/CHOP signaling pathway. It's worth noting that the relationship between KMT2D expression pattern and treatment effectiveness in clinical practice has yet to be further explored.
Publish Date 2019-08-16 00:41
Citation Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R. KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol 2019; 11(8): 599-621
URL https://www.wjgnet.com/1948-5204/full/v11/i8/599.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i8.599
Full Article (PDF) WJGO-11-599.pdf
Full Article (Word) WJGO-11-599.docx
Manuscript File FP6793_de25_CE1MS-edit2.docx
Answering Reviewers 42785-Answering reviewers.pdf
Audio Core Tip 42785-Audio core tip.mp3
Biostatistics Review Certificate 42785-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42785-Conflict-of-interest statement.pdf
Copyright License Agreement 42785-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 42785-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42785-Language certificate.pdf
Supplementary Material 42785-Supplementary material.docx
Peer-review Report 42785-Peer-review(s).pdf
Scientific Misconduct Check 42785-Scientific misconduct check.pdf
Scientific Editor Work List 42785-Scientific editor work list.pdf