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1/7/2019 10:39:41 AM | Browse: 23 | Download: 36
Publication Name World Journal of Gastroenterology
Manuscript ID 43024
Country of Manuscript Source Iran
Received
2018-10-19 01:57
Peer-Review Started
2018-10-19 05:28
To Make the First Decision
2018-11-29 09:18
Return for Revision
2018-11-30 03:51
Revised
2018-12-07 17:12
Second Decision
2018-12-13 09:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-13 17:40
Articles in Press
2018-12-13 17:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-24 01:22
Typeset the Manuscript
2019-01-06 10:19
Publish the Manuscript Online
2019-01-07 10:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Shahab Mahmoudvand, Somayeh Shokri, Reza Taherkhani and Fatemeh Farshadpour
ORCID
Author ORCID Number
Shahab Mahmoudvand http://orcid.org/0000-0002-9155-9939
Somayeh Shokri http://orcid.org/0000-0003-4609-3110
Reza Taherkhani http://orcid.org/0000-0001-6499-0531
Fatemeh Farshadpour http://orcid.org/0000-0002-8317-9573
Funding Agency and Grant Number
Correspondence To Fatemeh Farshadpour, PhD, Associate Professor, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Moallem Street, Bushehr 7514633341, Iran. f.farshadpour@bpums.ac.ir
Keywords Hepatitis C virus; Core protein; Transforming growth factor β; Vascular endothelial growth factor; Wnt/β-catenin; Cyclooxygenase-2; Peroxisome proliferator-activated receptor α; Hepatocellular carcinoma
Core Tip Hepatitis C virus (HCV) core protein can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of these signaling pathways by HCV core protein is implicated in the development of hepatocellular carcinoma (HCC). Considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC.
Publish Date 2019-01-07 10:39
Citation Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol 2019; 25(1): 42-58
Url https://www.wjgnet.com/1007-9327/full/v25/i1/42.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i1.42
Full Article (PDF) WJG-25-42.pdf
Full Article (Word) WJG-25-42.docx
Revised Manuscript 43024-Review.doc
Peer-review Report 43024-Peer-review(s).pdf
Answering Reviewers 43024-Answering reviewers.pdf
Scientific Misconduct Check 43024-Scientific misconduct check.pdf
Scientific Editor Work List 43024-Scientific editor work list.pdf
Audio Core Tip 43024-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 43024-Conflict-of-interest statement.pdf
Copyright License Agreement 43024-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 43024-Language certificate.pdf