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3/15/2019 6:26:39 AM | Browse: 13 | Download: 14
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 43092
Country of Manuscript Source China
Received
2018-10-26 03:26
Peer-Review Started
2018-10-26 07:08
To Make the First Decision
2018-11-16 02:25
Return for Revision
2018-11-28 01:59
Revised
2019-01-03 08:20
Second Decision
2019-01-08 13:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-09 02:40
Articles in Press
2019-01-09 02:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-14 06:27
Publish the Manuscript Online
2019-03-15 06:26
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Immunology
Manuscript type Basic Study
Article Title Human colorectal cancer cells frequently express IgG and display unique Ig repertoire
Manuscript Source Unsolicited Manuscript
All Author List Zi-Han Geng, Chun-Xiang Ye, Yan Huang, Hong-Peng Jiang, Ying-Jiang Ye, Shan Wang, Yuan Zhou, Zhan-Long Shen and Xiao-Yan Qiu
ORCID
Author(s) ORCID Number
Zi-Han Geng http://orcid.org/0000-0002-4367-6962
Chun-Xiang Ye http://orcid.org/0000-0001-7015-3166
Yan Huang http://orcid.org/0000-0001-8063-6110
Hong-Peng Jiang http://orcid.org/0000-0003-3815-5799
Ying-Jiang Ye http://orcid.org/0000-0002-7904-3163
Shan Wang http://orcid.org/0000-0002-4273-4307
Yuan Zhou http://orcid.org/0000-0001-5685-066X
Zhan-Long Shen http://orcid.org/0000-0002-4277-7067
Xiao-Yan Qiu http://orcid.org/0000-0002-4805-8362
Funding Agency and Grant Number
Funding Agency Grant Number
Key support projects of the National Natural Science Foundation's major research program 91642206
Major international cooperation projects of the National Natural Science Foundation 81320108020
Beijing Natural Science Foundation 7182171
Research institute fund of NHC Key Laboratory of Medical Immunology, Peking University BMU2018JDJS010
Non-profit central research institute fund of Chinese Academy of Medical Sciences 2018PT31039
Correspondence To Xiao-Yan Qiu, MD, PhD, Doctor, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Xueyuan Road, Beijing 100191, China. qiuxy@bjmu.edu.cn
Keywords Immunoglobulin repertoire; Sequencing; Colorectal cancer; VDJ pattern; VJ pattern
Core Tip It has been found that colon cancer cells can express immunoglobulin (Ig); however, the expression profile and features of the Ig repertoire in colon cancer cells remain unclear. Here, we first sorted colon cancer cells and normal cells from 7 patients with colon cancer. Using the Ig repertoire sequencing, we analyzed the features of the Ig heavy chain (IgH) repertoire in these cells. We found that Ig in colon cancer cells had a significant tendency to choose IgG compared to the other classes of IgH, and showed unique VHDJH patterns and somatic hypermutation hotspots, which might be potential targets for immune therapy for colon cancer.
Publish Date 2019-03-15 06:26
Citation Geng ZH, Ye CX, Huang Y, Jiang HP, Ye YJ, Wang S, Zhou Y, Shen ZL, Qiu XY. Human colorectal cancer cells frequently express IgG and display unique Ig repertoire. World Journal of Gastrointestinal Oncology 2019; 11(3): 195-207
Url https://www.wjgnet.com/1948-5204/full/v11/i3/195.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i3.195
Full Article (PDF) WJGO-11-195.pdf
Full Article (Word) WJGO-11-195.docx
Manuscript File 43092-Review.docx
Answering Reviewers 43092-Answering reviewers.pdf
Audio Core Tip 43092-Audio core tip.m4a
Biostatistics Review Certificate 43092-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 43092-Conflict-of-interest statement.pdf
Copyright License Agreement 43092-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 43092-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 43092-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 43092-Language certificate.pdf
Peer-review Report 43092-Peer-review(s).pdf
Scientific Misconduct Check 43092-Scientific misconduct check.pdf
Scientific Editor Work List 43092-Scientific editor work list.pdf