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1/30/2019 5:59:07 AM | Browse: 104 | Download: 50
Publication Name World Journal of Gastroenterology
Manuscript ID 43106
Country of Manuscript Source China
2018-10-24 06:07
Peer-Review Started
2018-10-25 01:59
To Make the First Decision
2018-11-29 09:30
Return for Revision
2018-12-17 07:16
2019-01-10 06:42
Second Decision
2019-01-18 11:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-18 23:04
Articles in Press
2019-01-18 23:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-01-23 01:35
Typeset the Manuscript
2019-01-29 06:56
Publish the Manuscript Online
2019-01-30 05:59
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice
Manuscript Source Unsolicited Manuscript
All Author List Chang Xu, Kun Wang, Yu-Han Ding, Wen-Jing Li and Lei Ding
Author(s) ORCID Number
Chang Xu http://orcid.org/0000-0003-1634-0870
Kun Wang http://orcid.org/0000-0001-5342-5967
Yu-Han Ding http://orcid.org/0000-0001-9263-7364
Wen-Jing Li http://orcid.org/0000-0002-7814-7390
Lei Ding http://orcid.org/0000-0001-7350-8508
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81372585
National Natural Science Foundation of China 81772557
Beijing Health System High Level Training Plan of Health Technical Personnel 2014-3-048
Correspondence To Lei Ding, MD, PhD, Associate Professor, Chief Doctor, Surgeon, Surgical Oncologist, Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Tieyi Road 10, Haidian District, Beijing 100038, China. dinglei1005@126.com
Keywords Claudin-7; Gene knockout; Inflammation; Adenomas; Colorectal carcinoma
Core Tip The intestinal tract of conventional and intestinal specific Claudin-7 knockout mice was characterized by extensive and severe inflammation. The development of inducible conditional knockout mice can control the knockout of Claudin-7 in a temporal and compartment specific manner and prolong the survival time of mice, which exhibited atypical hyperplasia and adenoma in the intestine. This study revealed the inhibitory role that Claudin-7 plays in colorectal inflammation and colorectal cancer.
Publish Date 2019-01-30 05:59
Citation Xu C, Wang K, Ding YH, Li WJ, Ding L. Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice. World J Gastroenterol 2019; 25(5): 584-599
Url https://www.wjgnet.com/1007-9327/full/v25/i5/584.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i5.584
Full Article (PDF) WJG-25-584.pdf
Full Article (Word) WJG-25-584.docx
Manuscript File 43106-Review_Edited.docx
Answering Reviewers 43106-Answering reviewers.pdf
Audio Core Tip 43106-Audio core tip.m4a
Biostatistics Review Certificate 43106-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 43106-Conflict-of-interest statement.pdf
Copyright License Agreement 43106-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 43106-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 43106-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 43106-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 43106-Language certificate.pdf
Peer-review Report 43106-Peer-review(s).pdf
Scientific Misconduct Check 43106-Scientific misconduct check.pdf
Scientific Editor Work List 43106-Scientific editor work list.pdf