Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	4374
Country	United States

Received	2013-06-28 11:58
Peer-Review Started	2013-06-28 18:11
To Make the First Decision	2013-07-26 18:30
Return for Revision	2013-08-06 09:52
Revised	2013-11-07 13:49
Second Decision	2014-01-14 18:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-14 19:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-29 01:48
Typeset the Manuscript	2014-05-07 16:40
Publish the Manuscript Online	2014-05-12 15:50

ISSN	2218-6220 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Obstetrics & Gynecology
Manuscript Type	Autobiography
Article Title	Fetal lung surfactant and development alterations in intrahepatic cholestasis of pregnancy
Manuscript Source	Invited Manuscript
All Author List	Yi-Ling Ding, Li-Juan Zhang, Xin Wang, Qi-Chang Zhou, Na Li, Chang-Xiu Wang and Xiu-Quan Zhang
Funding Agency and Grant Number
Corresponding Author	Xiu-Quan Zhang, MD, Department of Obstetrics and Gynecology and Reproductive Genetics, University of Utah School of Medicine, 50 North Medical. Drive, Salt Lake City, UT 84132, United States. xiuquan.zhang@hsc.utah.edu
Key Words	Intrahepatic cholestasis of pregnancy; Total bile acid; Pulmonary surfactant; Surfactant protein; Phospholipids; Amniotic fluid lamellar body
Core Tip	We studied total bile acid (TBA) concentration in maternal, fetal and amniotic fluid and its relationship with fetal surfactant, surfactant protein A, amniotic lamellar body and fetal lung development. Results demonstrated that intrahepatic cholestasis of pregnancy (ICP) has higher TBA in maternal and fetal blood and amniotic fluid. The high concentration of TBA may affect fetal pulmonary surfactant production and fetal lung maturation. It calls attention to delayed maturation of fetal lungs in ICP patients and to take steps to carefully check and improve fetal pulmonary maturity.
Publish Date	2014-05-12 15:50
Citation	Ding YL, Zhang LJ, Wang X, Zhou QC, Li N, Wang CX, Zhang XQ. Fetal lung surfactant and development alterations in intrahepatic cholestasis of pregnancy. World J Obstet Gynecol 2014; 3(2): 78-84
URL	http://www.wjgnet.com/2218-6220/full/v3/i2/78.htm
DOI	http://dx.doi.org/10.5317/wjog.v3.i2.78

Full Article (PDF)	WJOG-3-78.pdf
Full Article (Word)	WJOG-3-78.doc
Manuscript File	4374-Review.doc
Answering Reviewers	4374-Answering reviewers.pdf
Copyright License Agreement	4374-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Statement of the Ethics Committee Approval.pdf
Peer-review Report	4374-Peer reviewer(s).pdf
Scientific Editor Work List	4374-Scientific editor work list.doc