Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	4379
Country

Received	2013-06-28 12:16
Peer-Review Started	2013-06-28 18:38
To Make the First Decision	2013-07-05 18:34
Return for Revision	2013-07-09 11:50
Revised	2013-07-23 01:51
Second Decision	2013-08-16 19:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-17 00:10
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-27 14:13
Publish the Manuscript Online	2013-09-05 13:09

ISSN	2220-3176 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Physiological functions and clinical implications of fibrinogen-like 2: A review
Manuscript Source
All Author List	Genyan Yang and W Craig Hooper
Funding Agency and Grant Number
Corresponding Author	W Craig Hooper, PhD, Clinical and Molecular Hemostasis Laboratory Branch, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E., Atlanta, GA 30329, United States. chooper@cdc.gov
Key Words	Fibrinogen-like 2; Prothrombinase; Immunosuppressor; Infectious disease
Core Tip	Fibrinogen-like 2 (FGL2) protein promotes coagulation as a prothrombinase, or acts as an immunosuppressor to repress function of T lymphocytes and dendritic cells and induce apoptosis of B lymphocytes. Ectopic expression of FGL2 has been proven relevant for the pathogenesis of viral infections. Induction of FGL2 in response to pathogen invasion causes focal prothrombin activation and fibrin deposition. This process may lead to inflammation, microvascular thrombosis, and subsequent organ failure. FGL2-mediated immunosuppression can facilitate pathogen proliferation and expansion. The understanding of FGL2-mediated pathophysiology offers an insight into biomarker development and clinical intervention of FGL2-associated medical conditions such as viral hepatitis.
Publish Date	2013-09-05 13:09
Citation	Yang G, Hooper WC. Physiological functions and clinical implications of fibrinogen-like 2: A review. World J Clin Infect Dis 2013; 3(3): 37-46
URL	http://www.wjgnet.com/2220-3176/full/v3/i3/37.htm
DOI	http://dx.doi.org/10.5495/wjcid.v3.i3.37

Full Article (PDF)	WJCID-3-37.pdf
Manuscript File	4379-Review.doc
Answering Reviewers	4379-Answering reviewers.pdf
Copyright License Agreement	4379-Copyright assignment.pdf
Peer-review Report	4379-Peer review(s).pdf
Scientific Editor Work List	4379-Scientific editor work list.doc