Publication Name	World Journal of Biological Chemistry
Manuscript ID	4421
Country	Austria

Received	2013-06-29 18:26
Peer-Review Started	2013-06-29 20:34
To Make the First Decision	2013-08-08 11:08
Return for Revision	2013-08-14 17:26
Revised	2013-08-20 23:03
Second Decision	2013-09-03 14:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-04 07:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-18 18:18
Publish the Manuscript Online	2013-12-06 18:20

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Virology
Manuscript Type	Review
Article Title	Rethinking quasispecies theory: From fittest type to cooperative consortia
Manuscript Source	Invited Manuscript
All Author List	Luis P Villarreal and Guenther Witzany
Funding Agency and Grant Number
Corresponding Author	Guenther Witzany, PhD, Telos-Philosophische Praxis, Vogelsangstrasse 18c, 5111 Buermoos, Austria. witzany@sbg.at
Key Words	Quasispecies; RNA stem-loops; Infectious agents; Cooperative interactions; Evolution
Core Tip	Single RNA stem-loops operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operates by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops (not individuals) are the basic players. We thus redefine quasispecies as RNA quasispecies consortia and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology.
Publish Date	2013-12-06 18:20
Citation	Villarreal LP, Witzany G. Rethinking quasispecies theory: From fittest type to cooperative consortia. World J Biol Chem 2013; 4(4): 79-90
URL	http://www.wjgnet.com/1949-8454/full/v4/i4/79.htm
DOI	http://dx.doi.org/10.4331/wjbc.v4.i4.79

Full Article (PDF)	WJBC-4-79.pdf
Manuscript File	4421-Review.doc
Answering Reviewers	4421-Answering reviewers.pdf
Copyright License Agreement	4421-Copyright assignment.pdf
Peer-review Report	4421-Peer review(s).pdf
Scientific Editor Work List	4421-Scientific editor work list.doc