Publication Name	World Journal of Gastroenterology
Manuscript ID	4423
Country	Iran

Received	2013-06-29 18:37
Peer-Review Started	2013-06-29 22:15
To Make the First Decision	2013-09-09 13:45
Return for Revision	2013-09-12 10:08
Revised	2013-09-21 19:14
Second Decision	2013-10-14 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-14 13:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-22 18:59
Typeset the Manuscript	2013-11-13 14:13
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Autoantibodies and an immune-based rat model of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Hadi Esmaily, Yara Sanei and Mohammad Abdollahi
Funding Agency and Grant Number
Corresponding Author	Mohammad Abdollahi, Professor, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Poursina Street, Tehran 1417614411, Iran. mohammad@tums.ac.ir
Key Words	Inflammatory bowel disease rat model; Pathogenesis; Barrier dysfunction; Microbial factor
Core Tip	We present a new hypothesis to distinguish the complex links between genetic susceptibility, barrier dysfunction, commensal and pathologic microbial factors and inflammatory response (especially autoantibodies) in the pathogenesis of inflammatory bowel disease (IBD). In our hypothesis, we suggest that prior activation of adaptive immunity against microbial flora antigens could initiate an IBD-like chronic inflammation if something like ethanol disturbs barrier function. If this hypothesis is supported with further experiments, it would illustrate unknown aspects of IBD pathogenesis. On this basis, we have developed a new immune-based model of IBD with the presence of antibodies against enteric bacterial antigens.
Publish Date	2013-12-18 09:53
Citation	Esmaily H, Sanei Y, Abdollahi M. Autoantibodies and an immune-based rat model of inflammatory bowel disease. World J Gastroenterol 2013; 19(43): 7569-7576
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7569.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7569

Full Article (PDF)	WJG-19-7569.pdf
Manuscript File	4423-Review.doc
Answering Reviewers	4423-Answering reviewers.pdf
Copyright License Agreement	4423-Copyright assignment.pdf
Peer-review Report	4423-Peer review(s).pdf
Scientific Editor Work List	4423-Scientific editor work list.doc