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3/28/2019 9:14:40 AM | Browse: 924 | Download: 1439
Publication Name World Journal of Gastroenterology
Manuscript ID 44541
Country/Territory Italy
Received
2018-11-14 03:28
Peer-Review Started
2018-11-14 08:01
To Make the First Decision
2019-01-07 01:51
Return for Revision
2019-01-07 06:06
Revised
2019-02-15 21:36
Second Decision
2019-02-22 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-23 05:22
Articles in Press
2019-02-23 05:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-27 10:09
Publish the Manuscript Online
2019-03-28 09:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis
Manuscript Source Invited Manuscript
All Author List Valentina Petito, Cristina Graziani, Loris R Lopetuso, Marco Fossati, Alessandra Battaglia, Vincenzo Arena, Domenico Scannone, Gianluca Quaranta, Andrea Quagliariello, Federica Del Chierico, Lorenza Putignani, Luca Masucci, Maurizio Sanguinetti, Alessandro Sgambato, Antonio Gasbarrini and Franco Scaldaferri
ORCID
Author(s) ORCID Number
Valentina Petito http://orcid.org/0000-0003-4396-1613
Cristina Graziani http://orcid.org/0000-0003-3578-7571
Loris R Lopetuso http://orcid.org/0000-0002-5747-2055
Marco Fossati http://orcid.org/0000-0002-9418-9953
Alessandra Battaglia http://orcid.org/0000-0001-7179-8900
Vincenzo Arena http://orcid.org/0000-0002-7562-223X
Domenico Scannone http://orcid.org/0000-0003-1448-5902
Gianluca Quaranta http://orcid.org/0000-0002-9094-2936
Andrea Quagliariello http://orcid.org/0000-0002-3941-3684
Federica Del Chierico http://orcid.org/0000-0002-4204-4736
Lorenza Putignani http://orcid.org/0000-0003-0134-2830
Luca Masucci http://orcid.org/0000-0002-8358-6726
Maurizio Sanguinetti http://orcid.org/0000-0002-9780-7059
Alessandro Sgambato http://orcid.org/0000-0002-9487-4563
Antonio Gasbarrini http://orcid.org/0000-0002-6230-1779
Franco Scaldaferri http://orcid.org/0000-0001-8334-7541
Funding Agency and Grant Number
Corresponding Author Loris R Lopetuso, MD, PhD, Academic Fellow, Senior Postdoctoral Fellow, UOC di Medicina Interna e Gastroenterologia, Area di Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Largo A Gemelli 8, Rome 00168, Italy. lopetusoloris@libero.it
Key Words Gut microbiota; Dextran sodium sulphate colitis; Immune system; T cells; Mesenchymal lymphnode; Tumor necrosis factor α
Core Tip The effect of the gut microbiota on the immune responses is not limited to the gut. On the other hand, autoimmune diseases, such as inflammatory bowel disease, are associated to different degree of dysbiosis involving different bacterial genera. Using a colitic mouse model, we aimed to evaluate the impact of anti-tumor necrosis factor α (TNFα) therapy on the intestinal immune system and gut microbiota concurrently. Healthy mice treated with anti-TNFα showed similar histological, microbial and immune features of untreated colitic mice, a lymphomononuclear infiltrate both at day 5 and 12 at hematoxylin and eosin staining, an increase of type 1 helper T lymphocytes and type 17 helper T lymphocytes at day 12, and finally increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.
Publish Date 2019-03-28 09:14
Citation Petito V, Graziani C, Lopetuso LR, Fossati M, Battaglia A, Arena V, Scannone D, Quaranta G, Quagliariello A, Del Chierico F, Putignani L, Masucci L, Sanguinetti M, Sgambato A, Gasbarrini A, Scaldaferri F. Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis. World J Gastroenterol 2019; 25(12): 1465-1477
URL https://www.wjgnet.com/1007-9327/full/v25/i12/1465.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i12.1465
Full Article (PDF) WJG-25-1465.pdf
Full Article (Word) WJG-25-1465.docx
Manuscript File 44541-Review.docx
Answering Reviewers 44541-Answering reviewers.pdf
Audio Core Tip 44541-Audio core tip.mp3
Biostatistics Review Certificate 44541-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44541-Conflict-of-interest statement.pdf
Copyright License Agreement 44541-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 44541-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 44541-Language certificate.pdf
Peer-review Report 44541-Peer-review(s).pdf
Scientific Misconduct Check 44541-Google-MA RY-2.png
Scientific Misconduct Check 44541-Scientific misconduct check.pdf
Scientific Editor Work List 44541-Scientific editor work list.pdf