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5/15/2019 10:34:38 AM | Browse: 145 | Download: 148
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 44659
Country of Manuscript Source China
2018-11-20 02:26
Peer-Review Started
2018-11-20 02:50
To Make the First Decision
2018-12-11 01:11
Return for Revision
2018-12-12 09:50
2018-12-17 03:00
Second Decision
2019-01-03 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-04 00:10
Articles in Press
2019-01-04 00:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-01-16 16:45
Typeset the Manuscript
2019-05-14 02:19
Publish the Manuscript Online
2019-05-15 10:34
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Integrative and Complementary Medicine
Manuscript Type Basic Study
Article Title Qingjie Fuzheng Granules inhibits colorectal cancer cells growth by PI3K/AKT and ERK pathways
Manuscript Source Unsolicited Manuscript
All Author List Hong Yang, Jian-Xin Liu, Hai-Xia Shang, Shan Lin, Jin-Yan Zhao and Jiu-Mao Lin
Author(s) ORCID Number
Hong Yang http://orcid.org/0000-0003-4800-5719
Jian-Xin Liu http://orcid.org/0000-0003-2460-7635
Hai-Xia Shang http://orcid.org/0000-0002-3057-502X
Shan Lin http://orcid.org/0000-0003-4061-6734
Jin-Yan Zhao http://orcid.org/0000-0001-9771-4656
Jiu-Mao Lin http://orcid.org/0000-0002-5312-6286
Funding Agency and Grant Number
Funding Agency Grant Number
Project Funding of the Scientific Research Foundation of Traditional Chinese Medicine of Fujian Provincial Health and Family Planning Commission 2017FJZYZY203
the Training of Young and Middle-Aged Backbone Personnel of Fujian Provincial Health and Family Planning Commission 2016-ZQN-67
Corresponding author Jiu-Mao Lin, PhD, Academic Fellow, Academic Research, Senior Research Fellow, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou 350122, Fujian Province, China. linjiumao@fjtcm.edu.cn
Keywords Qingjie Fuzheng Granules; Colorectal cancer; Proliferation; Apoptosis; PI3K/AKT; ERK
Core Tip To study the effect and mechanism of Qingjie Fuzheng Granules (QFG) on colorectal cancer (CRC) cells, we measured cell viability and cytotoxicity by performing MTT and LDH assays; evaluated the role of QFG in cell proliferation by conducting colony formation, cell cycle and western blot assays; evaluated the role of QFG in cell apoptosis by assessing Hoechst 33258, Annexin-V/PI and western blot assays. Furthermore, the activation of PI3K/AKT and ERK signaling pathways was examined using the western blot assay to investigate the possible mechanism. All results demonstrated that QFG inhibited CRC cells growth by suppressing PI3K/AKT and ERK signaling pathways.
Publish Date 2019-05-15 10:34
Citation Yang H, Liu JX, Shang HX, Lin S, Zhao JY, Lin JM. Qingjie Fuzheng Granules inhibits colorectal cancer cells growth by PI3K/AKT and ERK pathways. World J Gastroenterol Oncol 2019; 11(5): 377-392
Url https://www.wjgnet.com/1948-5204/full/v11/i5/377.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i5.377
Full Article (PDF) WJGO-11-377.pdf
Manuscript File 44659-Review.doc
Answering Reviewers 44659-Answering reviewers.pdf
Audio Core Tip 44659-Audio core tip.mp3
Biostatistics Review Certificate 44659-Biostatistics Review Certificate.pdf
Conflict-of-Interest Disclosure Form 44659-Conflict-of-interest statement.pdf
Copyright License Agreement 44659-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 44659-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 44659-Institutional Animal Care and Use Committee Approval Form or Document.pdf
Institutional Review Board Approval Form or Document 44659-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 44659-Language certificate.pdf
Peer-review Report 44659-Peer-review(s).pdf
Scientific Misconduct Check 44659-Scientific misconduct check.pdf
Scientific Editor Work List 44659-Scientific editor work list.pdf