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Publication Name World Journal of Gastroenterology
Manuscript ID 4466
Country/Territory China
2013-07-01 10:40
Peer-Review Started
2013-07-01 13:22
To Make the First Decision
2013-07-30 17:18
Return for Revision
2013-07-31 09:39
2013-08-10 21:03
Second Decision
2013-08-16 19:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-17 00:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-09-10 11:29
Typeset the Manuscript
2013-09-19 10:03
Publish the Manuscript Online
2013-10-18 17:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells
Manuscript Source Invited Manuscript
All Author List Ming-Zhu Sun, Shuang-Suo Dang, Wen-Jun Wang, Xiao-Li Jia, Song Zhai, Xin Zhang, Mei Li, Ya-Ping Li and Meng Xun
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81170393
Corresponding Author Shuang-Suo Dang, PhD, Professor, Director of Department of Infectious Diseases, the Second Affiliated Hospital of College of Medicine, Xi'an Jiaotong University, No. 157, Xi Wu Road, Xi'an 710004, Shaanxi Province, China. dang212@126.com
Key Words Hepatitis C virus cell culture system; Cytokeratin 8; Up-regulation; Eukaryotic expression; Apoptosis
Core Tip In this study, we observed that cytokeratin 8 (CK8) levels are elevated in hepatitis C virus (HCV) cell culture system and its ectopic expression decreased the proliferation and induced apoptosis of SMMC7721 cells. CK8 up-regulation might have a functional role in HCV infection and pathogenesis, and could be a promising target for the treatment of HCV infection.
Publish Date 2013-10-18 17:02
Citation Sun MZ, Dang SS, Wang WJ, Jia XL, Zhai S, Zhang X, Li M, Li YP, Xun M. Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells. World J Gastroenterol 2013; 19(37): 6178-6187
URL http://www.wjgnet.com/1007-9327/full/v19/i37/6178.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i37.6178
Full Article (PDF) WJG-19-6178.pdf
Manuscript File 4466-Review.docx
Answering Reviewers 4466-Answering reviewers.pdf
Copyright License Agreement 4466-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4466-Language certificate.pdf
Peer-review Report 4466-Peer review(s).pdf
Scientific Editor Work List 4466-Scientific editor work list.doc