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4/26/2019 3:39:24 AM | Browse: 78 | Download: 29
Publication Name World Journal of Hepatology
Manuscript ID 44984
Country of Manuscript Source Brazil
Received
2018-12-11 01:52
Peer-Review Started
2018-12-11 09:31
To Make the First Decision
2019-01-14 01:05
Return for Revision
2019-01-27 01:16
Revised
2019-02-23 00:01
Second Decision
2019-03-15 09:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 14:36
Articles in Press
2019-03-16 14:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-31 20:37
Typeset the Manuscript
2019-04-24 05:55
Publish the Manuscript Online
2019-04-26 03:39
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model
Manuscript Source Invited Manuscript
All Author List Francielle Graus-Nunes, Felipe de Oliveira Santos, Thatiany de Souza Marinho, Carolline Santos Miranda, Sandra Barbosa-da-Silva and Vanessa Souza-Mello
ORCID
Author(s) ORCID Number
Francielle Graus-Nunes http://orcid.org/0000-0002-6212-3116
Felipe de Oliveira Santos http://orcid.org/0000-0003-4693-2682
Thatiany de Souza Marinho http://orcid.org/0000-0001-9976-9466
Carolline Santos Miranda http://orcid.org/0000-0001-5488-0179
Sandra Barbosa-da-Silva http://orcid.org/0000-0003-3866-0912
Vanessa Souza-Mello http://orcid.org/0000-0002-2510-9569
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação Carlos Chagas Filho de Apoio à Pesquisa do Estado do Rio de Janeiro (FAPERJ E-26/202.888/2015
Correspondence To Vanessa Souza-Mello, PhD, Adjunct Professor, Laboratório de Morfometria, Metabolismo e Doenças Cardiovasculares, Departamento de Anatomia, Instituto de Biologia Roberto Alcântara Gomes, Av. 28 de setembro 87 fundos, Rio de Janeiro 20551-030, Brazil. v.souzamello@gmail.com
Keywords Liver; Telmisartan; Losartan; Obesity; Angiotensin II type 1 receptor; C57BL/6 mouse
Core Tip Studies that address the modulation of local renin-angiotensin system (RAS) have gathered pace as it was established that obese subjects exhibit overexpression of the components of classical RAS in organs like the liver. Herein we show pieces of evidence that two different angiotensin II receptor blockers can modulate the intrahepatic RAS, with favored angiotensin-converting enzyme (ACE) 2/rMAS axis over ACE1/angiotensin II type 1 receptor in mice fed a high-fat diet. These actions could mitigate hepatic steatosis through reduced hepatic triacylglycerol levels along with decreased body mass and better glycemic control. These drugs could be a viable option to treat non-alcoholic fatty liver disease in obese and/or hypertensive patients.
Publish Date 2019-04-26 03:39
Citation Graus-Nunes F, Santos FO, Marinho TS, Miranda CS, Barbosa-da-Silva S, Souza-Mello V. Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model. World J Hepatol 2019; 11(4): 359-369
Url https://www.wjgnet.com/1948-5182/full/v11/i4/359.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i4.359
Full Article (PDF) WJH-11-359.pdf
Full Article (Word) WJH-11-359.docx
Manuscript File FP6802_de26_CE1MS-edit2-2.docx
Answering Reviewers 44984-Answering reviewers.pdf
Audio Core Tip 44984-Audio core tip.mp3
Biostatistics Review Certificate 44984-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44984-Conflict-of-interest statement.pdf
Copyright License Agreement 44984-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 44984-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 44984-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 44984-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 44984-Language certificate.pdf
Peer-review Report 44984-Peer-review(s).pdf
Scientific Misconduct Check 44984-Scientific misconduct check.pdf
Scientific Editor Work List 44984-Scientific editor work list.pdf