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3/20/2019 5:32:10 AM | Browse: 130 | Download: 91
Publication Name World Journal of Gastroenterology
Manuscript ID 45066
Country of Manuscript Source China
2018-12-15 07:46
Peer-Review Started
2018-12-17 07:16
To Make the First Decision
2019-01-07 01:48
Return for Revision
2019-01-07 05:31
2019-01-22 05:01
Second Decision
2019-01-25 10:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-26 05:32
Articles in Press
2019-01-26 05:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-19 06:51
Publish the Manuscript Online
2019-03-20 05:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients
Manuscript Source Unsolicited Manuscript
All Author List Lung-Yi Mak, Wai-Pan To, Danny Ka-Ho Wong, James Fung, Fen Liu, Wai-Kay Seto, Ching-Lung Lai and Man-Fung Yuen
Author(s) ORCID Number
Lung-Yi Mak http://orcid.org/0000-0002-2266-3935
Wai-Pan To http://orcid.org/not applicable
Danny Ka-Ho Wong http://orcid.org/0000-0001-9078-5005
James Fung http://orcid.org/0000-0002-1286-8902
Fen Liu http://orcid.org/Not_applicable
Wai-Kay Seto http://orcid.org/0000-0002-9012-313X
Ching-Lung Lai http://orcid.org/0000-0002-5927-2436
Man-Fung Yuen http://orcid.org/0000-0001-7985-7725
Funding Agency and Grant Number
Corresponding author Man-Fung Yuen, DSc, FRCP (C), MBBS, MD, MRCP, PhD, Professor, Professor, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road 102, Hong Kong , China. mfyuen@hkucc.hku.hk
Keywords Hepatocellular carcinoma; Hepatitis B; Liver fibrosis; Mac-2 binding protein glycosylation isomer; Biomarker
Core Tip Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel marker to assess severity of liver disease. The aim of this study was to assess its role in prediction of incident hepatocellular carcinoma (HCC) in patients with chronic hepatitis B who were prospectively followed-up for a median duration of 13.1 years. High serum M2BPGi increased HCC risk by 4-5 folds. If M2BPGi is below the threshold (0.68 cut-off index), there is > 99% chance that the patient will not develop liver cancer in the subsequent 15 years.
Publish Date 2019-03-20 05:32
Citation Mak LY, To WP, Wong DKH, Fung J, Liu F, Seto WK, Lai CL, Yuen MF. Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients. World J Gastroenterol 2019; 25(11): 1398-1408
Url https://www.wjgnet.com/1007-9327/full/v25/i11/1398.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i11.1398
Full Article (PDF) WJG-25-1398.pdf
Full Article (Word) WJG-25-1398.docx
Manuscript File 45066-Review.docx
Answering Reviewers 45066-Answering reviewers.pdf
Audio Core Tip 45066-Audio core tip.mp3
Biostatistics Review Certificate 45066-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45066-Conflict-of-interest statement.pdf
Copyright License Agreement 45066-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 45066-Institutional review board statement.pdf
Supplementary Material 45066-Supplementary material.pdf
Peer-review Report 45066-Peer-review(s).pdf
Scientific Misconduct Check 45066-Scientific misconduct check.pdf
Scientific Editor Work List 45066-Scientific editor work list.pdf