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5/25/2019 9:31:40 AM | Browse: 718 | Download: 1019
Publication Name World Journal of Stem Cells
Manuscript ID 45091
Country/Territory United Kingdom
Received
2019-01-16 01:56
Peer-Review Started
2019-01-16 12:40
To Make the First Decision
2019-01-29 23:59
Return for Revision
2019-01-31 01:33
Revised
2019-02-22 13:29
Second Decision
2019-03-19 05:47
Accepted by Journal Editor-in-Chief
2019-03-20 13:31
Accepted by Company Editor-in-Chief
2019-03-26 16:21
Articles in Press
2019-03-26 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-05-24 06:26
Publish the Manuscript Online
2019-05-25 09:31
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Review
Article Title Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells
Manuscript Source Unsolicited Manuscript
All Author List Kate Elizabeth Hawkins and Michael Duchen
ORCID
Author(s) ORCID Number
Kate Elizabeth Hawkins http://orcid.org/0000-0001-6666-4238
Michael Duchen http://orcid.org/0000-0003-2548-4294
Funding Agency and Grant Number
Corresponding Author Kate Elizabeth Hawkins, PhD, Postdoc, Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom. kate.hawkins@merck.com
Key Words Induced pluripotent stem cells; Alzheimer’s disease; Mitochondria
Core Tip Alzheimer’s disease (AD) is a huge burden on the healthcare system and on society. At present, there are no therapeutic approaches that address the underlying causes of this devastating disease, largely because we lack understanding of the underlying molecular mechanisms. Induced pluripotent stem cells (iPSCs) from AD or Down syndrome patients can be used to elucidate these molecular mechanisms, therefore presenting a novel approach to this problem. In this review, we focus on the ability of iPSC models to gain insight into the mitochondrial dysfunction that occurs during AD and therefore identify novel drug targets.
Publish Date 2019-05-25 09:31
Citation Hawkins KE, Duchen MR, Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells. World J Stem Cells 2019; 11(5): 236-253
URL https://www.wjgnet.com/1948-0210/full/v11/i5/236.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i5.236
Full Article (PDF) WJSC-11-236.pdf
Full Article (Word) WJSC-11-236.docx
Manuscript File 45091-Review.docx
Answering Reviewers 45091-Answering reviewers.pdf
Audio Core Tip 45091-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 45091-Conflict-of-interest statement.pdf
Copyright License Agreement 45091-Copyright license agreement.pdf
Peer-review Report 45091-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 45091-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 45091-Scientific misconduct check.pdf
Scientific Editor Work List 45091-Scientific editor work list.pdf