Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	4525
Country

Received	2013-07-04 09:01
Peer-Review Started	2013-07-04 11:32
To Make the First Decision	2013-07-19 08:44
Return for Revision	2013-07-25 17:27
Revised	2013-08-07 23:23
Second Decision	2013-09-18 10:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-18 11:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-14 15:21
Publish the Manuscript Online	2013-11-08 10:03

ISSN	2219-2808 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Review
Article Title	Bacterial colonization and intestinal mucosal barrier development
Manuscript Source
All Author List	Xiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li and Jing Lin
Funding Agency and Grant Number
Corresponding Author	Jing Lin, MD, Division of Newborn Medicine, Department of Pediatrics, Kravis Children’s Hospital of the Icahn School of Medicine at Mount Sinai, Box 1508, One Gustave L. Levy Place, New York, NY 10029-6574, United States. jing.lin@mssm.edu
Key Words	Bacterial colonization; Intestinal barrier; Intestinal microflora; Microbiota; Neonatal necrotizing enterocolitis; Nosocomial infection; Premature infants; Short chain fatty acids
Core Tip	This review summarizes recent advances in understanding the complex ecosystem of intestinal microbiota and its role in regulating intestinal barrier function and a few common pediatric diseases. There is increasingly recognition that the stimulation of initial intestinal microbial colonization is important for proper maturation of the innate immune system and continued regulation and maintenance of intestinal barrier function. Disruption of the establishment of a stable normal gut microflora may contribute to the pathogenesis of diseases including inflammatory bowel disease, nosocomial infection, and neonatal necrotizing enterocolitis in premature infants.
Publish Date	2013-11-08 10:03
Citation	Huang XZ, Zhu LB, Li ZR, Lin J. Bacterial colonization and intestinal mucosal barrier development. World J Clin Pediatr 2013; 2(4): 46-53
URL	http://www.wjgnet.com/2219-2808/full/v2/i4/46.htm
DOI	http://dx.doi.org/10.5409/wjcp.v2.i4.46

Full Article (PDF)	WJCP-2-46.pdf
Manuscript File	4525-Review.doc
Answering Reviewers	4525-Answering reviewers.pdf
Copyright License Agreement	4525-Copyright assignment.pdf
Peer-review Report	4525-Peer reviews.pdf
Scientific Editor Work List	4525-Scientific editor work list.doc