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Publication Name World Journal of Gastroenterology
Manuscript ID 45308
Country/Territory Spain
Received
2018-12-24 02:09
Peer-Review Started
2018-12-25 04:47
To Make the First Decision
2019-01-23 03:35
Return for Revision
2019-01-24 01:17
Revised
2019-02-25 15:34
Second Decision
2019-03-01 07:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-02 03:43
Articles in Press
2019-03-02 03:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-27 00:13
Publish the Manuscript Online
2019-04-04 03:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection
Manuscript Source Invited Manuscript
All Author List Cristina Godoy, David Tabernero, Sara Sopena, Josep Gregori, Maria Francesca Cortese, Carolina González, Rosario Casillas, Marçal Yll, Ariadna Rando, Rosa Maria López, Josep Quer, Gloria Gonzalez-Aseguinolaza, Rafael Esteban, Mar Riveiro-Barciela, Maria Buti and Francisco Rodriguez-Frias
ORCID
Author(s) ORCID Number
Cristina Godoy http://orcid.org/0000-0001-5037-1916
David Tabernero http://orcid.org/0000-0002-1146-4084
Sara Sopena http://orcid.org/0000-0002-3309-5486
Josep Gregori http://orcid.org/0000-0002-4253-8015
Maria Francesca Cortese http://orcid.org/0000-0002-4318-532X
Carolina González http://orcid.org/0000-0002-0169-5874
Rosario Casillas http://orcid.org/0000-0002-6758-6734
Marçal Yll http://orcid.org/0000-0002-7030-3360
Ariadna Rando http://orcid.org/0000-0003-4555-7286
Rosa Maria López http://orcid.org/0000-0002-8450-6986
Josep Quer http://orcid.org/0000-0003-0014-084X
Gloria Gonzalez-Aseguinolaza http://orcid.org/0000-0002-1600-4562
Rafael Esteban http://orcid.org/0000-0001-5280-392X
Mar Riveiro-Barciela http://orcid.org/0000-0001-9309-2052
Maria Buti http://orcid.org/0000-0002-0732-3078
Francisco Rodriguez-Frias http://orcid.org/0000-0002-9128-7013
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Salud Carlos III and European Regional Development Fund PI15/00856
Instituto de Salud Carlos III and European Regional Development Fund PI17/02233
Corresponding Author David Tabernero, MSc, PhD, Postdoc, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain. david.tabernero@ciberehd.org
Key Words Hepatitis B virus; Hepatitis delta virus; Hepatitis B X gene; Next-generation sequencing; Viral quasispecies; Hepatitis B virus-hepatitis delta virus interaction
Core Tip Hepatitis B virus (HBV) replication is lower in the presence of hepatitis delta virus (HDV), but little is known about the mechanism of this interaction. HBV X gene quasispecies study in HBV/HDV infection could provide data regarding this interaction. With use of next-generation sequencing, we analyzed HBV quasispecies complexity and found a trend to greater complexity in chronic HDV and chronic HBV infection (CI, previously termed inactive carriers) than in chronic hepatitis B. This suggests that HDV may drive the HBV quasispecies to acquire a situation of diversity similar to that of CI patients.
Publish Date 2019-04-04 03:01
Citation Godoy C, Tabernero D, Sopena S, Gregori J, Cortese MF, González C, Casillas R, Yll M, Rando A, López-Martinez R, Quer J, González-Aseguinolaza G, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frias F. Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection. World J Gastroenterol 2019;25(13): 1566-1579
URL https://www.wjgnet.com/1007-9327/full/v25/i13/1566.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i13.1566
Full Article (PDF) WJG-25-1566.pdf
Full Article (Word) WJG-25-1566.docx
The ARRIVE Guidelines 45308-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 45308-Review.docx
Answering Reviewers 45308-Answering reviewers.pdf
Audio Core Tip 45308-Audio core tip.mp3
Biostatistics Review Certificate 45308-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45308-Conflict-of-interest statement.pdf
Copyright License Agreement 45308-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45308-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 45308-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 45308-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45308-Language certificate.pdf
Supplementary Material 45308-Supplementary material.pdf
Peer-review Report 45308-Peer-review(s).pdf
Scientific Misconduct Check 45308-Scientific misconduct check.pdf
Scientific Editor Work List 45308-Scientific editor work list.pdf