ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection
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Manuscript Source |
Invited Manuscript |
All Author List |
Cristina Godoy, David Tabernero, Sara Sopena, Josep Gregori, Maria Francesca Cortese, Carolina González, Rosario Casillas, Marçal Yll, Ariadna Rando, Rosa Maria López, Josep Quer, Gloria Gonzalez-Aseguinolaza, Rafael Esteban, Mar Riveiro-Barciela, Maria Buti and Francisco Rodriguez-Frias |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Instituto de Salud Carlos III and European Regional Development Fund |
PI15/00856 |
Instituto de Salud Carlos III and European Regional Development Fund |
PI17/02233 |
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Corresponding Author |
David Tabernero, MSc, PhD, Postdoc, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain. david.tabernero@ciberehd.org |
Key Words |
Hepatitis B virus; Hepatitis delta virus; Hepatitis B X gene; Next-generation sequencing; Viral quasispecies; Hepatitis B virus-hepatitis delta virus interaction |
Core Tip |
Hepatitis B virus (HBV) replication is lower in the presence of hepatitis delta virus (HDV), but little is known about the mechanism of this interaction. HBV X gene quasispecies study in HBV/HDV infection could provide data regarding this interaction. With use of next-generation sequencing, we analyzed HBV quasispecies complexity and found a trend to greater complexity in chronic HDV and chronic HBV infection (CI, previously termed inactive carriers) than in chronic hepatitis B. This suggests that HDV may drive the HBV quasispecies to acquire a situation of diversity similar to that of CI patients. |
Publish Date |
2019-04-04 03:01 |
Citation |
Godoy C, Tabernero D, Sopena S, Gregori J, Cortese MF, González C, Casillas R, Yll M, Rando A, López-Martinez R, Quer J, González-Aseguinolaza G, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frias F. Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection. World J Gastroenterol 2019;25(13): 1566-1579 |
URL |
https://www.wjgnet.com/1007-9327/full/v25/i13/1566.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v25.i13.1566 |