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4/13/2019 6:00:06 AM | Browse: 19 | Download: 18
Publication Name World Journal of Gastroenterology
Manuscript ID 45590
Country of Manuscript Source China
Received
2019-01-06 07:17
Peer-Review Started
2019-01-07 10:31
To Make the First Decision
2019-02-14 01:04
Return for Revision
2019-02-15 03:10
Revised
2019-03-06 06:45
Second Decision
2019-03-15 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 18:00
Articles in Press
2019-03-16 18:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-25 14:14
Typeset the Manuscript
2019-04-10 10:09
Publish the Manuscript Online
2019-04-13 06:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Hong Xiang, Li Yang, Xing Zhang, Xiao-Hua Ma, Run-Chen Miao, Jing-Xian Gu, Yu-Nong Fu, Qing Yao, Jing-Yao Zhang, Chang Liu, Ting Lin and Kai Qu
ORCID
Author(s) ORCID Number
Xiao-Hong Xiang http://orcid.org/0000-0002-9020-9187
Li Yang http://orcid.org/0000-0002-8325-8335
Xing Zhang http://orcid.org/0000-0001-9568-8124
Xiao-Hua Ma http://orcid.org/0000-0002-5546-8458
Run-Chen Miao http://orcid.org/0000-0003-1651-3970
Jing-Xian Gu http://orcid.org/0000-0002-6183-4004
Yu-Nong Fu http://orcid.org/0000-0001-8324-0613
Qing Yao http://orcid.org/0000-0002-4904-9214
Jing-Yao Zhang http://orcid.org/0000-0002-1177-0401
Chang Liu http://orcid.org/0000-0003-1892-3957
Ting Lin http://orcid.org/0000-0003-3825-6178
Kai Qu http://orcid.org/0000-0002-1138-3727
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81773128
the National Natural Science Foundation of China 81871998
the Natural Science Basic Research Plan in Shaanxi Province of China 2018JM7013
the Natural Science Basic Research Plan in Shaanxi Province of China 2017JM8039
the Research Fund for Young Star of Science and Technology in Shaanxi Province 2018KJXX-022
China Postdoctoral Science Foundation 2018M641000
Correspondence To Kai Qu, MD, PhD, Professor, Research Assistant Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, West Yanta Road 277, Xi'an 710061, Shaanxi Province, China. qukaixjtu@163.com
Keywords Senescence-associated genes; Hepatocellular carcinoma; Overall survival; Risk model; Asian patients
Core Tip In the present study, we identified a total of 42 senescence-associated genes (SAGs) and found seven of them were significantly downregulated in senescent cells and upregulated in HCC tissues. By using the least absolute shrinkage and selection operator, we constructed a seven-SAG signature that could predict the overall survival (OS) of hepatocellular carcinoma. This seven-SAG signature was further validated and developed in another independent dataset from The Cancer Genome Atlas project. Moreover, our risk score system showed better utility in predicting the OS than classic serum biomarker α-fetoprotein.
Publish Date 2019-04-13 06:00
Citation Xiang XH, Yang L, Zhang X, Ma XH, Miao RC, Gu JX, Fu YN, Yao Q, Zhang JY, Liu C, Lin T, Qu K. Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma. World J Gastroenterol 2019; 25(14): 1715-1728
Url https://www.wjgnet.com/1007-9327/full/v25/i14/1715.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i14.1715
Full Article (PDF) WJG-25-1715.pdf
Full Article (Word) WJG-25-1715.docx
Manuscript File 45590-Review_Edited.doc
Answering Reviewers 45590-Answering reviewers.pdf
Audio Core Tip 45590-Audio core tip.WAV
Biostatistics Review Certificate 45590-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45590-Conflict-of-interest statement.pdf
Copyright License Agreement 45590-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45590-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 45590-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45590-Language certificate.pdf
Peer-review Report 45590-Peer-review(s).pdf
Scientific Misconduct Check 45590-Scientific misconduct check.pdf
Scientific Editor Work List 45590-Scientific editor work list.pdf