Publication Name	World Journal of Gastroenterology
Manuscript ID	4560
Country	Türkiye

Received	2013-07-08 08:36
Peer-Review Started	2013-07-08 14:28
To Make the First Decision	2013-07-26 18:39
Return for Revision	2013-08-06 10:31
Revised	2013-09-01 19:30
Second Decision	2013-09-16 17:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 06:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-08 15:27
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Serum concentrations of insulin-like growth factor-binding protein 5 in Crohn's disease
Manuscript Source	Invited Manuscript
All Author List	Gupse Adali, Elif Yorulmaz, Seyma Ozkanli, Celal Ulasoglu, Baris Bayraktar, Alev Orhun, Yasar Colak and Ilyas Tuncer
Funding Agency and Grant Number
Corresponding Author	Gupse Adali, MD, Department of Gastroenterology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey. gupseadali@gmail.com
Key Words	Crohn's disease; Insulin-like growth factor-binding protein 5; Stricture; Immunohistochemistry; Enzyme-linked immunosorbent assay
Core Tip	Previous studies have suggested that insulin-like growth factors are important for the growth and development of visceral smooth muscle. In particular, increased insulin-like growth factor-binding protein 5 expression has been described in inflamed and fibrotic intestinal tissue. In this study, we aim to investigate the possible role of insulin-like growth factor-binding protein 5 in Crohn's disease with stricture involvement. Crohn's disease patients had lower serum levels of IGFBP-5 compared to healthy controls. The results of the study suggest that additional research is necessary to explain the low circulating levels of IGFBP-5 in Crohn's disease patients.
Publish Date	2014-01-20 16:41
Citation	Adali G, Yorulmaz E, Ozkanli S, Ulasoglu C, Bayraktar B, Orhun A, Colak Y, Tuncer I. Serum concentrations of insulin-like growth factor-binding protein 5 in Crohn’s disease. World J Gastroenterol 2013; 19(47): 9049-9056
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/9049.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.9049

Full Article (PDF)	WJG-19-9049.pdf
Manuscript File	4560-Review.doc
Answering Reviewers	4560-Answering reviewers.pdf
Copyright License Agreement	4560-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	4560-Language certificate.doc
Peer-review Report	4560-Peer reviewer(s).pdf
Scientific Editor Work List	4560-Scientific editor work list.doc