| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Characterization and sequencing analysis of inflammatory factor-induced changes to mesenchymal stem cell exosomes and exosomal microRNA
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Huang, Wen-Feng Luo, Yu-Feng Ye, Li Lin, Zhe Wang, Ming-Hua Luo, Qi-De Song, Xue-Ping He, Han-Wei Chen, Yi Kong and Yu-Kuan Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Panyu Science and Technology Plan Medical General Project |
2018-Z04-47 |
| Guangzhou Health Science and Technology Project |
20191A011120 |
|
| Corresponding Author |
Yu-Kuan Tang, MD, Director, Doctor, Department of Minimally Invasive Interventional Radiology, Guangzhou Panyu Central Hospital, 8 East Fuyu Road Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong Province, China. tyk20126@126.com |
| Key Words |
Mesenchymal stem cells; Exosomes; MiRNA; Inflammatory cytokines; Angiogenesis; |
| Core Tip |
The morphology and quantity of mesenchymal stem cells exosomes (MSCs-exo) are impacted in different inflammatory cytokines environment. Inflammatory cytokines impair the ability of MSCs-exo to promote angiogenesis. For instance, the tumor necrosis factor α, and interleukin 6 groups exhibited decreased numbers of angiogenesis-related microRNA (miRNA), such as miR-196a-5p, miR-17-5p, miR-146b-5p, miR-21-3p and miR-320. The same groups also downregulated angiogenesis-related signaling pathways, such as PI3K-AKT and VEGF. Inflammatory cytokines may lead to exosomal miRNAs that abnormally impact cellular components, molecular function and biological process, particularly angiogenesis-related miRNAs. |
| Publish Date |
2019-10-22 07:13 |
| Citation |
Huang C, Luo WF, Ye YF, Lin L, Wang Z, Luo MH, Song QD, He XP, Chen HW, Kong Y, Tang YK. Characterization and sequencing analysis of inflammatory factor-induced changes to mesenchymal stem cell exosomes and exosomal microRNA. World J Stem Cells 2019; 11(10):859-890 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i10/859.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i10.859 |
