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4/18/2019 5:48:09 AM | Browse: 243 | Download: 189
Publication Name World Journal of Gastroenterology
Manuscript ID 46175
Country/Territory United States
2019-02-06 03:20
Peer-Review Started
2019-02-06 14:26
To Make the First Decision
2019-03-06 01:59
Return for Revision
2019-03-06 02:17
2019-03-20 19:10
Second Decision
2019-03-22 08:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-25 04:39
Articles in Press
2019-03-25 04:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-17 00:55
Publish the Manuscript Online
2019-04-18 05:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
Manuscript Source Invited Manuscript
All Author List Enrique Rozengurt and Guido Eibl
Author(s) ORCID Number
Enrique Rozengurt http://orcid.org/0000-0002-7838-9170
Guido Eibl http://orcid.org/0000-0003-3497-4527
Funding Agency and Grant Number
Corresponding author Guido Eibl, MD, Director, Professor, Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 72-236 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, United States. geibl@mednet.ucla.edu
Keywords Pancreatic cancer; Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif; Oncogenic Kras; Obesity; Signaling network and loops
Core Tip The identification of signaling networks that underlie risk factor promoted pancreatic cancer development and progression is of paramount importance to prevent or intercept this lethal disease. Accumulating evidence suggests that several core signaling pathways downstream of oncogenic Kras, augmented by environmental conditions, e.g., obesity, converge on Yes-associated protein (YAP) and WW-domain-containing transcriptional co-activator with PDZ-binding motif (TAZ), transcriptional co-activators in the Hippo pathway. Statins and metformin, widely used Food and Drug Administration-approved drugs, show great promise to intercept this disease by disrupting or inhibiting this amplifying network at multiple points converging onto YAP/TAZ.
Publish Date 2019-04-18 05:48
Citation Rozengurt E, Eibl G. Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. World J Gastroenterol 2019;25(15): 1797-1816
Url https://www.wjgnet.com/1007-9327/full/v25/i15/1797.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i15.1797
Full Article (PDF) WJG-25-1797.pdf
Full Article (Word) WJG-25-1797.docx
Manuscript File 46175-Review.docx
Answering Reviewers 46175-Answering reviewers.pdf
Audio Core Tip 46175-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 46175-Conflict-of-interest statement.pdf
Copyright License Agreement 46175-Copyright license agreement.pdf
Peer-review Report 46175-Peer-review(s).pdf
Scientific Misconduct Check 46175-Google-MA RY-1.png
Scientific Misconduct Check 46175-Google-MA RY-2.png
Scientific Misconduct Check 46175-Scientific misconduct check.pdf
Scientific Editor Work List 46175-Scientific editor work list.pdf