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Articles Published Processes
7/6/2019 11:29:12 AM | Browse: 838 | Download: 1484
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Received |
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2019-02-03 14:15 |
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Peer-Review Started |
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2019-02-11 02:20 |
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To Make the First Decision |
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2019-04-18 03:35 |
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Return for Revision |
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2019-04-19 06:11 |
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Revised |
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2019-04-22 11:37 |
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Second Decision |
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2019-05-03 03:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-05-03 11:00 |
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Articles in Press |
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2019-05-03 11:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-10 01:13 |
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Typeset the Manuscript |
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2019-07-05 00:28 |
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Publish the Manuscript Online |
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2019-07-06 11:29 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Report |
| Article Title |
Synchronous multiple primary gastrointestinal cancers with CDH1 mutations: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mu-Ni Hu, Wei Lv, Rui-Yue Hu, Yi-Fan Si, Xiao-Wen Lu, Yan-Juan Deng and Huan Deng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation of China |
81770624 |
| National Science Foundation of China |
81860490 |
| Foundation of Jiangxi Educational Committee |
GJJ160048 |
| Foundation of Health and Family Planning Commission of Jiangxi Province |
20171098 |
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| Corresponding Author |
Huan Deng, MD, PhD, Associate Professor, Department of Pathology, the Fourth Affiliated Hospital of Nanchang University, 133 South Guangchang Road, Nanchang 330003, Jiangxi Province, China. beandeng@ncu.edu.cn;beandeng@hotmail.com |
| Key Words |
Multiple primary cancer; CDH1; Signet ring cell carcinoma; Stomach; Colon; Case report |
| Core Tip |
A 62-year-old woman was admitted with abdominal pain for one week. Gastrointestinal endoscope showed multiple small polypoid lesions in both stomach and colorectum. A diagnosis of primary signet ring cell carcinoma was established based on the combination of pathological and imageologic evaluation. E-cadherin expression was downregulated in the malignant cells, where β-catenin aberrantly translocated into cytoplasm and nucleus. DNA sequencing indicated C.57T>G and C.1418A>T on CDH1, suggesting the important role of CDH1 mutations in the pathogenesis of synchronous multiple primary gastrointestinal cancers. |
| Publish Date |
2019-07-06 11:29 |
| Citation |
Hu MN, Lv W, Hu RY, Si YF, Lu XW, Deng YJ, Deng H. Synchronous multiple primary gastrointestinal cancers with CDH1 mutations: A case report. World J Clin Cases 2019;7(13): 1703-1710 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i13/1703.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i13.1703 |
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