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7/6/2019 11:29:12 AM | Browse: 75 | Download: 54
Publication Name World Journal of Clinical Cases
Manuscript ID 46215
Country of Manuscript Source China
Received
2019-02-03 14:15
Peer-Review Started
2019-02-11 02:20
To Make the First Decision
2019-04-18 03:35
Return for Revision
2019-04-19 06:11
Revised
2019-04-22 11:37
Second Decision
2019-05-03 03:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-03 11:00
Articles in Press
2019-05-03 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-10 01:13
Typeset the Manuscript
2019-07-05 00:28
Publish the Manuscript Online
2019-07-06 11:29
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript type Case Report
Article Title Synchronous multiple primary gastrointestinal cancers with CDH1 mutations: A case report
Manuscript Source Unsolicited Manuscript
All Author List Mu-Ni Hu, Wei Lv, Rui-Yue Hu, Yi-Fan Si, Xiao-Wen Lu, Yan-Juan Deng and Huan Deng
ORCID
Author(s) ORCID Number
Mu-Ni Hu http://orcid.org/0000-0002-6207-3999
Wei Lv http://orcid.org/0000-0002-3305-5222
Rui-Yue Hu http://orcid.org/0000-0002-2885-0125
Yi-Fan Si http://orcid.org/0000-0002-3370-6689
Xiao-Wen Lu http://orcid.org/0000-0002-4344-1223
Yan-Juan Deng http://orcid.org/0000-0001-7334-8575
Huan Deng http://orcid.org/0000-0002-1596-2013
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Foundation of China 81770624
National Science Foundation of China 81860490
Foundation of Jiangxi Educational Committee GJJ160048
Foundation of Health and Family Planning Commission of Jiangxi Province 20171098
Correspondence To Huan Deng, MD, PhD, Associate Professor, Department of Pathology, the Fourth Affiliated Hospital of Nanchang University, 133 South Guangchang Road, Nanchang 330003, Jiangxi Province, China. beandeng@ncu.edu.cn;beandeng@hotmail.com
Keywords Multiple primary cancer; CDH1; Signet ring cell carcinoma; Stomach; Colon; Case report
Core Tip A 62-year-old woman was admitted with abdominal pain for one week. Gastrointestinal endoscope showed multiple small polypoid lesions in both stomach and colorectum. A diagnosis of primary signet ring cell carcinoma was established based on the combination of pathological and imageologic evaluation. E-cadherin expression was downregulated in the malignant cells, where β-catenin aberrantly translocated into cytoplasm and nucleus. DNA sequencing indicated C.57T>G and C.1418A>T on CDH1, suggesting the important role of CDH1 mutations in the pathogenesis of synchronous multiple primary gastrointestinal cancers.
Publish Date 2019-07-06 11:29
Citation Hu MN, Lv W, Hu RY, Si YF, Lu XW, Deng YJ, Deng H. Synchronous multiple primary gastrointestinal cancers with CDH1 mutations: A case report. World J Clin Cases 2019;7(13): 1703-1710
Url https://www.wjgnet.com/2307-8960/full/v7/i13/1703.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i13.1703
Full Article (PDF) WJCC-7-1703.pdf
Full Article (Word) WJCC-7-1703.docx
Manuscript File 46215-Review_Edited.docx
Answering Reviewers 46215-Answering reviewers.pdf
Audio Core Tip 46215-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 46215-Conflict-of-interest statement.pdf
Copyright License Agreement 46215-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46215-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 46215-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 46215-Language certificate.pdf
Peer-review Report 46215-Peer-review(s).pdf
Scientific Misconduct Check 46215-Scientific misconduct check.pdf
Scientific Editor Work List 46215-Scientific editor work list.pdf