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3/15/2019 7:18:19 AM | Browse: 36 | Download: 20
Publication Name World Journal of Diabetes
Manuscript ID 46286
Country of Manuscript Source United States
2019-02-06 03:07
Peer-Review Started
2019-02-09 14:00
To Make the First Decision
2019-02-20 00:33
Return for Revision
2019-02-21 04:03
2019-03-04 20:42
Second Decision
2019-03-07 11:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-09 01:17
Articles in Press
2019-03-09 01:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-14 09:09
Publish the Manuscript Online
2019-03-15 07:18
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Cohort Study
Article Title Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members
Manuscript Source Unsolicited Manuscript
All Author List Maureen M Leonard, Stephanie Camhi, Victoria Kenyon, Rebecca A Betensky, Shu Yan, Craig Sturgeon and Alessio Fasano
Author(s) ORCID Number
Maureen M Leonard http://orcid.org/0000-0002-5955-5102
Stephanie Camhi http://orcid.org/0000-0003-0691-5773
Victoria Kenyon http://orcid.org/0000-0002-7051-0124
Rebecca A Betensky http://orcid.org/0000-0002-3793-1437
Shu Yan http://orcid.org/0000-0003-4864-5134
Craig Sturgeon http://orcid.org/0000-0002-5311-0903
Alessio Fasano http://orcid.org/0000-0002-2134-0261
Funding Agency and Grant Number
Funding Agency Grant Number
Nutrition Obesity Research Center at Harvard P30-DK04561
The Harvard Clinical and Translational Science Center, the Harvard Catalyst NIH Award UL1 TR001102
Correspondence To Maureen M Leonard, MD, MSc, Instructor, Clinical Director, Department of Pediatric Gastroenterology, Mass General Hospital for Children, 55 Fruit Street (Jackson 14), Boston, Massachusetts02114, United States. mleonard7@partners.org
Keywords Screening; Gluten; Diabetic; Coeliac; Haptoglobin; Human leukocyte antigen
Core Tip Serological screening for celiac disease (CD) autoimmunity in subjects with type 1 diabetes (T1D) and their first-degree relatives (FDRs) found an underestimation of CD by 2 fold in T1D patients and 2.8 fold in their FDRs. Participants with T1D who carry DR7-DQ2/DR4-DQ8 were more likely to screen positive for CD autoimmunity. There was no association between carrying zonulin genetics and an increased risk of developing CD in our cohort. Patients with T1D and their FDRs have an increased risk of developing CD compared to the general population and, given the often-asymptomatic nature of disease, physicians should have a low threshold for screening.
Publish Date 2019-03-15 07:18
Citation Leonard MM, Camhi S, Kenyon V, Betensky RA, Sturgeon C, Yan S, Fasano A. Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members. World J Diabetes 2019; 10(3): 189-199
Url https://www.wjgnet.com/1948-9358/full/v10/i3/189.htm
DOI https://dx.doi.org/10.4239/wjd.v10.i3.189
Full Article (PDF) WJD-10-189.pdf
Full Article (Word) WJD-10-189.docx
Manuscript File 46286-Review.docx
Answering Reviewers 46286-Answering reviewers.pdf
Audio Core Tip 46286-Audio core tip.mp3
Biostatistics Review Certificate 46286-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46286-Conflict-of-interest statement.pdf
Copyright License Agreement 46286-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46286-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 46286-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 46286-Institutional review board statement.pdf
Peer-review Report 46286-Peer-review(s).pdf
Scientific Misconduct Check 46286-Scientific misconduct check.pdf
Scientific Editor Work List 46286-Scientific editor work list.pdf