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3/15/2019 7:18:19 AM | Browse: 35 | Download: 30
Publication Name World Journal of Diabetes
Manuscript ID 46296
Country of Manuscript Source Jordan
2019-02-06 03:03
Peer-Review Started
2019-02-10 14:42
To Make the First Decision
2019-02-20 00:34
Return for Revision
2019-02-21 04:25
2019-03-08 20:08
Second Decision
2019-03-12 09:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 23:10
Articles in Press
2019-03-12 23:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-14 09:09
Publish the Manuscript Online
2019-03-15 07:18
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Biochemistry and Molecular Biology
Manuscript type Case Control Study
Article Title Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes
Manuscript Source Unsolicited Manuscript
All Author List Ismail Sami Mahmoud, Ayat Homsi, Hamzeh Al-Ameer, Jihad Alzyoud, Mais Darras, Mohammad Al Shhab, Malek Zihlif, Ma’mon Hatmal and Walhan Alshaer
Author(s) ORCID Number
Ismail Sami Mahmoud http://orcid.org/0000-0002-6210-9832
Ayat Homsi http://orcid.org/0000-0003-0973-6455
Hamzeh Al-Ameer http://orcid.org/0000-0002-1681-6747
Jihad Alzyoud http://orcid.org/0000-0001-9646-0746
Mais Darras http://orcid.org/0000-0001-6708-2993
Mohammad Al Shhab http://orcid.org/0000-0003-0160-8264
Malek Zihlif http://orcid.org/0000-0002-8005-3908
Ma’mon Hatmal http://orcid.org/0000-0003-1745-8985
Walhan Alshaer http://orcid.org/0000-0003-2946-7328
Funding Agency and Grant Number
Correspondence To Ismail Sami Mahmoud, PhD, Doctor, researcher and lecturer, Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa 13133, Jordan. ismails@hu.edu.jo
Keywords Regulatory factor X6; Genetic variant; Diabetes; DNA binding domain
Core Tip Regulatory Factor X6 (RFX6) protein plays a key role in the differentiation of pancreatic beta cells as well as insulin production and secretion. Several lines of evidence have indicated that RFX6 binding to DNA could be disrupted in diabetes; however, the mechanism underlying this process is still unknown. In this case-control study, we analysed the genotype of RFX6-DNA binding domain in diabetes patients in comparison to healthy controls. Our results indicate the absence of any significant genetic variant in the DNA binding domain that could affect the function of RFX6 in type 2 diabetes.
Publish Date 2019-03-15 07:18
Citation Mahmoud IS, Homsi A, Al-Ameer HJ, Alzyoud J, Darras M, Shhab MA, Zihlif M, Hatmal MM, Alshaer W. Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes. World J Diabetes 2019; 10(3): 181-188
Url https://www.wjgnet.com/1948-9358/full/v10/i3/181.htm
DOI https://dx.doi.org/10.4239/wjd.v10.i3.181
Full Article (PDF) WJD-10-181.pdf
Full Article (Word) WJD-10-181.docx
Manuscript File 46296-Review.docx
Answering Reviewers 46296-Answering reviewers.pdf
Audio Core Tip 46296-Audio core tip.m4a
Biostatistics Review Certificate 46296-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46296-Conflict-of-interest statement.pdf
Copyright License Agreement 46296-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 46296-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 46296-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46296-Language certificate.pdf
Peer-review Report 46296-Peer-review(s).pdf
Scientific Misconduct Check 46296-Scientific misconduct check.pdf
Scientific Editor Work List 46296-Scientific editor work list.pdf