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8/26/2019 10:16:55 AM | Browse: 814 | Download: 1143
Publication Name World Journal of Stem Cells
Manuscript ID 46607
Country/Territory China
Received
2019-02-18 09:56
Peer-Review Started
2019-02-20 06:10
To Make the First Decision
2019-06-05 06:41
Return for Revision
2019-06-06 04:02
Revised
2019-06-26 07:27
Second Decision
2019-07-01 00:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-17 18:03
Articles in Press
2019-07-17 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-22 12:28
Publish the Manuscript Online
2019-08-26 10:16
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anatomy & Morphology
Manuscript Type Review
Article Title Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms
Manuscript Source Invited Manuscript
All Author List Fei Yin, Wen-Ying Wang and Wen-Hua Jiang
ORCID
Author(s) ORCID Number
Fei Yin http://orcid.org/0000-0002-3679-8160
Wen-Ying Wang http://orcid.org/0000-0002-0838-8412
Wen-Hua Jiang http://orcid.org/0000-0002-9159-9869
Funding Agency and Grant Number
Funding Agency Grant Number
the Natural Science Foundation of Jilin Province of China 20190201010JC
Corresponding Author Wen-Hua Jiang, MD, Adjunct Professor, Dept Histol & Embryol, Basic Medical College of Jilin University, 126 Xinmin Street, Changchun 130021, Jilin Province, China. jiangwenhua468@163.com
Key Words Human umbilical cord mesenchymal stem cells; Liver fibrosis; Hepatocyte-like cells; Mechanism; Cell therapy; Paracrine effect
Core Tip Liver fibrosis is a major global health problem, for which no efficient therapy is available. Cell therapy, particularly involving human umbilical cord mesenchymal stem cells (known as hUC-MSCs), represents a promising therapeutic strategy, based mainly on the cells’ paracrine effects, transdifferentiation capacity and immunomodulatory function. In this review, we discuss the characteristics of hUC-MSCs, focusing on the possible mechanisms of these cells to ameliorate liver fibrosis, based upon evidence from in vitro and in vivo studies as well as ongoing clinical trials. This review also includes a discussion of the current status of the field and its future prospects.
Publish Date 2019-08-26 10:16
Citation Yin F, Wang WY, Jiang WH. Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms. World J Stem Cells 2019; 11(8):548-564
URL https://www.wjgnet.com/1948-0210/full/v11/i8/548.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i8.548
Full Article (PDF) WJSC-11-548.pdf
Full Article (Word) WJSC-11-548.docx
Manuscript File 46607-Review.docx
Answering Reviewers 46607-Answering reviewers.pdf
Audio Core Tip 46607-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46607-Conflict-of-interest statement.pdf
Copyright License Agreement 46607-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46607-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46607-Language certificate.pdf
Peer-review Report 46607-Peer-review(s).pdf
Scientific Misconduct Check 46607-Scientific misconduct check.pdf
Scientific Editor Work List 46607-Scientific editor work list.pdf