| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Report |
| Article Title |
Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Maristella Saponara, Valentina Indio, Carmine Pizzi, Elena-Daniela Serban, Milena Urbini, Annalisa Astolfi, Pasquale Paolisso, Sofia Martin Suarez, Margherita Nannini, Davide Pacini, Valentina Agostini, Ornella Leone, Valentina Ambrosini, Giuseppe Tarantino, Stefano Fanti, Fabio Niro, Francesco Buia, Domenico Attina' and Maria Abbondanza Pantaleo |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Maristella Saponara, MD, Academic Research, Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Bologna, Italy. maristella.saponara@unibo.it |
| Key Words |
Cardiac sarcoma; Myxofibrosarcoma; Whole transcriptome sequencing; Doxorubicin; Gemcitabine; Case report |
| Core Tip |
We present the case of an elderly woman affected by myxofibrosarcoma of the left atrium, a rare histotype of cardiac sarcoma. She underwent surgery, but, unfortunately, disease recurred. Therefore, she started first and second line chemotherapy with doxorubicin and then gemcitabine, obtaining good and durable radiologic response and complete metabolic response. Accurate histologic description is reported and molecular characterization of the tumor, by whole transcriptome sequencing, is also encompassed in order to better characterize this rare cancer and possibly identify pathognomonic molecular events or gene expression profiles shared with other sarcomas amenable for targeted medical therapy. |
| Publish Date |
2019-09-29 10:56 |
| Citation |
Saponara M, Indio V, Pizzi C, Serban E, Urbini M, Astolfi A, Paolisso P, Suarez SM, Nannini M, Pacini D, Agostini V, Leone O, Ambrosini V, Tarantino G, Fanti S, Niro F, Buia F, AttinàD, Pantaleo MA. Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report. World J Clin Cases 2019; 7(19):3018-3026 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i19/3018.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i19.3018 |
