Publication Name	World Journal of Gastroenterology
Manuscript ID	47403
Country	United States

Received	2019-03-15 03:06
Peer-Review Started	2019-03-15 06:18
To Make the First Decision	2019-04-11 08:25
Return for Revision	2019-04-12 00:46
Revised	2019-04-25 16:55
Second Decision	2019-05-17 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-18 12:45
Articles in Press	2019-05-18 12:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-04 07:11
Publish the Manuscript Online	2019-07-06 06:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Revisiting the liver’s role in transplant alloimmunity
Manuscript Source	Invited Manuscript
All Author List	Nitin Abrol, Caroline C Jadlowiec and Timucin Taner
ORCID	Author(s) ORCID Number Nitin Abrol http://orcid.org/0000-0002-9948-314X Caroline C Jadlowiec http://orcid.org/0000-0001-7860-9519 Timucin Taner http://orcid.org/0000-0003-0641-2930
Funding Agency and Grant Number
Corresponding Author	Timucin Taner, FACS, MD, PhD, Associate Professor, Surgeon, William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, United States. taner.timucin@mayo.edu
Key Words	Liver transplantation; Alloimmunity; Liver-kidney transplant; Tolerance; Rejection
Core Tip	The liver not only protects itself from host alloimmune responses, but also modulates alloimmune responses to other simultaneously transplanted solid organs like heart or kidney. The titer of donor specific alloantibodies decreases after liver transplantation, making transplantation of other solid organs possible even in highly sensitized high-risk patients. The immune cells from the liver allograft cross-talk with recipient immune cells and modulate the immune system towards tolerance. The cross-talk between these cells suppress the genes involved in alloimmunity and upregulate the genes involved in tissue repair and metabolism.
Publish Date	2019-07-06 06:23
Citation	Abrol N, Jadlowiec CC, Taner T. Revisiting liver’s role in transplant alloimmunity. World J Gastroenterol 2019; 25(25): 3123-3135
URL	https://www.wjgnet.com/1007-9327/full/v25/i25/3123.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i25.3123

Full Article (PDF)	WJG-25-3123.pdf
Full Article (Word)	WJG-25-3123.docx
Manuscript File	47403-Review.docx
Answering Reviewers	47403-Answering reviewers.pdf
Audio Core Tip	47403-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	47403-Conflict-of-interest statement.pdf
Copyright License Agreement	47403-Copyright license agreement.pdf
Peer-review Report	47403-Peer-review(s).pdf
Scientific Misconduct Check	47403-Scientific misconduct check.pdf
Scientific Editor Work List	47403-Scientific editor work list.pdf