| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment and outcomes
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Qian Yang, Jin Ye, Xin Li, Qian Li and Yu-Hu Song |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No.81570555 |
| National Natural Science Foundation of China |
No.81770582 |
|
| Corresponding Author |
Yu-Hu Song, MD, PhD, Chief Doctor, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, No 1277, Jiefang Avenue, Wuhan 430022, Hubei Province, China. 2009xh0899@hust.edu.cn |
| Key Words |
Hepatic sinusoidal obstruction syndrome; Pyrrolizidine alkaloids; Hepatic sinusoidal endothelial cells; Pyrrole-protein adducts; Diagnostic criteria; Symptomatic treatment |
| Core Tip |
Hepatic sinusoidal obstruction syndrome (HSOS), also named hepatic veno-occlusive disease, is a hepatic vascular disease presenting with abdominal distension, painful hepatomegaly, jaundice, and weight gain. The intake of pyrrolizidine alkaloids (PAs) is one of the major etiologies of HSOS in China. Unfortunately, PAs-induced HSOS has not been extensively studied up to now. Here, we describe the pathogenesis, clinical profiles, diagnosis, treatment and outcomes of patients with PAs-induced HSOS. |
| Publish Date |
2019-07-28 10:51 |
| Citation |
Yang XQ, Ye J, Li X, Li Q, Song YH. Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment and outcomes. World J Gastroenterol 2019; 25(28): 3753-3763 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i28/3753.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i28.3753 |
