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8/7/2019 7:09:17 AM | Browse: 31 | Download: 10
Publication Name World Journal of Gastroenterology
Manuscript ID 47558
Country of Manuscript Source Germany
Received
2019-03-18 04:04
Peer-Review Started
2019-03-19 00:47
To Make the First Decision
2019-05-14 01:15
Return for Revision
2019-05-15 01:16
Revised
2019-05-21 18:23
Second Decision
2019-06-26 10:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-03 01:13
Articles in Press
2019-07-03 01:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-10 20:50
Typeset the Manuscript
2019-08-06 02:30
Publish the Manuscript Online
2019-08-07 07:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Minireviews
Article Title Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches
Manuscript Source Invited Manuscript
All Author List Joseph Tintelnot and Alexander Stein
ORCID
Author(s) ORCID Number
Joseph Tintelnot http://orcid.org/0000-0003-4619-9433
Alexander Stein http://orcid.org/0000-0002-9768-0086
Funding Agency and Grant Number
Correspondence To Alexander Stein, MD, Assistant Professor, Department of Internal Medicine II (Oncology Center), University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany. a.stein@uke.de
Keywords Immunotherapy; Combination; Colorectal cancer; Metastatic; Adjuvant;
Core Tip Colorectal cancer is not responsive to single agent programmed death 1/ligand 1 or cytotoxic T lymphocyte-associated antigen-4 inhibitors, beside the subset of mismatch repair deficient or microsatellite instable tumors. Thus, a variety of combination approaches with chemotherapy, targeted therapy, toll like receptor agonists, local ablation or oncolytic viruses are currently evaluated to enhance immunogenicity of mismatch repair proficient colorectal cancers. Here we review current clinical evidence, challenges and novel approaches in ongoing clinical programs.
Publish Date 2019-08-07 07:09
Citation Tintelnot J, Stein A. Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches. World J Gastroenterol 2019; 25(29): 3920-3928
Url https://www.wjgnet.com/1007-9327/full/v25/i29/3920.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i29.3920
Full Article (PDF) WJG-25-3920.pdf
Full Article (Word) WJG-25-3920.docx
Manuscript File FP6909_de16_CE1MS_edit2-2.docx
Answering Reviewers 47558-Answering reviewers.pdf
Audio Core Tip 47558-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47558-Conflict-of-interest statement.pdf
Copyright License Agreement 47558-Copyright license agreement.pdf
Peer-review Report 47558-Peer-review(s).pdf
Scientific Misconduct Check 47558-Scientific misconduct check.pdf
Scientific Editor Work List 47558-Scientific editor work list.pdf