ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Orthopedics |
Manuscript Type |
Review |
Article Title |
Dysfunctional stem and progenitor cells impair fracture healing with age
|
Manuscript Source |
Invited Manuscript |
All Author List |
Diane R Wagner, Sonali Karnik, Zachary Gunderson, Jeffery Nielsen, Alanna Fennimore, Hunter Promer, Jonathan Lowery, M Terry Loghmani, Philip S Low, Todd McKinley, Melissa A Kacena, Matthias Clauss and Jiliang Li |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Indiana University Collaborative Research Grant |
|
Indiana Clinical and Translational Sciences Institute |
NIH UL1TR001108 |
National Institutes of Health |
R01 AR069657 |
National Institutes of Health |
R01 AR060863 |
National Institutes of Health |
R01 AG060621 |
Veteran's Affairs |
BX003751 |
|
Corresponding Author |
Diane R Wagner, PhD, Associate Professor, Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, 723 W. Michigan St. SL 260, Indianaposlis, IN 46202, United States. wagnerdi@iupui.edu |
Key Words |
Fracture healing; Aging; Bone; Angiogenesis; Mesenchymal stem cells; Endothelial progenitor cells |
Core Tip |
Bone fractures in the elderly are a significant issue, due to the prevalence of the problem, the difficulty of treatment, and the severe consequences of the extended healing period. The delay in fracture healing with advanced age has been attributed to both the decreased number and function of mesenchymal stem cells that regenerate the bone and the inferior performance of endothelial progenitor cells that direct angiogenesis. Some suggested avenues for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. |
Publish Date |
2019-06-26 11:43 |
Citation |
Wagner DR, Karnik S, Gunderson ZJ, Nielsen JJ, Fennimore A, Promer HJ, Lowery JW, Loghmani MT, Low PS, McKinley TO, Kacena MA, Clauss M, Li J. Dysfunctional stem and progenitor cells impair fracture healing with age. World J Stem Cells 2019; 11(6): 281-296 |
URL |
https://www.wjgnet.com/1948-0210/full/v11/i6/281.htm |
DOI |
https://dx.doi.org/10.4252/wjsc.v11.i6.281 |