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6/26/2019 11:43:52 AM | Browse: 825 | Download: 947
Publication Name World Journal of Stem Cells
Manuscript ID 47678
Country/Territory United States
Received
2019-03-21 05:34
Peer-Review Started
2019-03-22 09:14
To Make the First Decision
2019-04-24 06:00
Return for Revision
2019-04-24 08:19
Revised
2019-04-26 23:08
Second Decision
2019-05-29 01:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-13 02:33
Articles in Press
2019-06-13 02:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-24 01:58
Publish the Manuscript Online
2019-06-26 11:43
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Review
Article Title Dysfunctional stem and progenitor cells impair fracture healing with age
Manuscript Source Invited Manuscript
All Author List Diane R Wagner, Sonali Karnik, Zachary Gunderson, Jeffery Nielsen, Alanna Fennimore, Hunter Promer, Jonathan Lowery, M Terry Loghmani, Philip S Low, Todd McKinley, Melissa A Kacena, Matthias Clauss and Jiliang Li
ORCID
Author(s) ORCID Number
Diane R Wagner http://orcid.org/0000-0001-8013-0777
Sonali Karnik http://orcid.org/0000-0002-1905-2885
Zachary Gunderson http://orcid.org/0000-0003-0469-3644
Jeffery Nielsen http://orcid.org/0000-0002-2329-1299
Alanna Fennimore http://orcid.org/0000-0002-3285-3310
Hunter Promer http://orcid.org/0000-0003-0047-9456
Jonathan Lowery http://orcid.org/0000-0002-9942-2945
M Terry Loghmani http://orcid.org/0000-0003-2286-0733
Philip S Low http://orcid.org/0000-0001-9042-5528
Todd McKinley http://orcid.org/0000-0001-6354-7685
Melissa A Kacena http://orcid.org/0000-0001-7293-0088
Matthias Clauss http://orcid.org/0000-0001-5180-3899
Jiliang Li http://orcid.org/0000-0002-8180-3205
Funding Agency and Grant Number
Funding Agency Grant Number
Indiana University Collaborative Research Grant
Indiana Clinical and Translational Sciences Institute NIH UL1TR001108
National Institutes of Health R01 AR069657
National Institutes of Health R01 AR060863
National Institutes of Health R01 AG060621
Veteran's Affairs BX003751
Corresponding Author Diane R Wagner, PhD, Associate Professor, Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, 723 W. Michigan St. SL 260, Indianaposlis, IN 46202, United States. wagnerdi@iupui.edu
Key Words Fracture healing; Aging; Bone; Angiogenesis; Mesenchymal stem cells; Endothelial progenitor cells
Core Tip Bone fractures in the elderly are a significant issue, due to the prevalence of the problem, the difficulty of treatment, and the severe consequences of the extended healing period. The delay in fracture healing with advanced age has been attributed to both the decreased number and function of mesenchymal stem cells that regenerate the bone and the inferior performance of endothelial progenitor cells that direct angiogenesis. Some suggested avenues for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics.
Publish Date 2019-06-26 11:43
Citation Wagner DR, Karnik S, Gunderson ZJ, Nielsen JJ, Fennimore A, Promer HJ, Lowery JW, Loghmani MT, Low PS, McKinley TO, Kacena MA, Clauss M, Li J. Dysfunctional stem and progenitor cells impair fracture healing with age. World J Stem Cells 2019; 11(6): 281-296
URL https://www.wjgnet.com/1948-0210/full/v11/i6/281.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i6.281
Full Article (PDF) WJSC-11-281.pdf
Full Article (Word) WJSC-11-281.docx
Manuscript File 47678-Review.docx
Answering Reviewers 47678-Answering reviewers.pdf
Audio Core Tip 47678-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47678-Conflict-of-interest statement.pdf
Copyright License Agreement 47678-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47678-Grant application form(s).pdf
Peer-review Report 47678-Peer-review(s).pdf
Scientific Misconduct Check 47678-Scientific misconduct check.pdf
Scientific Editor Work List 47678-Scientific editor work list.pdf