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11/28/2019 8:04:08 AM | Browse: 138 | Download: 80
Publication Name World Journal of Stem Cells
Manuscript ID 47708
Country/Territory Italy
2019-03-23 06:33
Peer-Review Started
2019-03-26 00:37
To Make the First Decision
2019-08-06 02:55
Return for Revision
2019-08-20 03:54
2019-09-05 14:15
Second Decision
2019-10-14 09:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-14 18:20
Articles in Press
2019-10-14 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-25 22:13
Typeset the Manuscript
2019-11-13 04:46
Publish the Manuscript Online
2019-11-28 08:04
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology and Pharmacy
Manuscript Type Review
Article Title Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug induced adverse events
Manuscript Source Invited Manuscript
All Author List Elena Genova, Federica Cavion, Marianna Lucafò, Luigina De Leo, Marco Pelin, Gabriele Stocco and Giuliana Decorti
Author(s) ORCID Number
Elena Genova http://orcid.org/0000-0002-6692-6573
Federica Cavion http://orcid.org/0000-0001-6901-5866
Marianna Lucafò http://orcid.org/0000-0003-1355-3782
Luigina De Leo http://orcid.org/0000-0003-4013-1630
Marco Pelin http://orcid.org/0000-0002-4306-7411
Gabriele Stocco http://orcid.org/0000-0003-0964-5879
Giuliana Decorti http://orcid.org/0000-0002-9714-6246
Funding Agency and Grant Number
Funding Agency Grant Number
Italian Ministry of Health (IRCCS Burlo Garofolo) RC 7_2014, RC 10_2019
progetto fondo di ricerca Ateneo, Università di Trieste FRA2018
Corresponding author Gabriele Stocco, PhD, Assistant Professor, Department of Life Sciences, University of Trieste, via Fleming 22, Trieste 34127, Italy. stoccog@units.it
Keywords Induced pluripotent stem cells; Organoids; Adverse drug reactions; Intestinal toxicity; Hepatic toxicity; Pancreatic toxicity
Core Tip Adverse drug reactions (ADRs) are one of the major clinical problems, especially in pediatric patients, who may respond differently to drugs with respect to adults. This up-to-date review focuses on the employment of patient-derived induced pluripotent stem cells and related systems (i.e., stem cell-derived organoids) to study ADRs in the adult and, wherever available, in the pediatric field. We especially focused on the intestinal, hepatic, pancreatic, renal, cardiac and neuronal levels, in which the major ADRs are usually observed. Due to their genetic and physiological species-specific differences, these models may be accurate in predicting drug toxicity.
Publish Date 2019-11-28 08:04
Citation Genova E, Cavion F, Lucafò M, De Leo L, Pelin M, Stocco G, Decorti G. Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug induced adverse events. World J Stem Cells 2019; 11(12): 1020-1044
Url https://www.wjgnet.com/1948-0210/full/v11/i12/1020.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i12.1020
Full Article (PDF) WJSC-11-1020.pdf
Full Article (Word) WJSC-11-1020.docx
Manuscript File FP7048_ce36_CE1MS_edit2-1.docx
Answering Reviewers 47708-Answering reviewers.pdf
Audio Core Tip 47708-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 47708-Conflict-of-interest statement.pdf
Copyright License Agreement 47708-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47708-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 47708-Language certificate.pdf
Peer-review Report 47708-Peer-review(s).pdf
Scientific Misconduct Check 47708-Scientific misconduct check.pdf
Scientific Editor Work List 47708-Scientific editor work list.pdf