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Articles Published Processes
11/28/2019 8:04:08 AM | Browse: 1119 | Download: 734
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Received |
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2019-03-23 06:33 |
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Peer-Review Started |
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2019-03-26 00:37 |
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To Make the First Decision |
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2019-08-06 02:55 |
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Return for Revision |
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2019-08-20 03:54 |
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Revised |
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2019-09-05 14:15 |
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Second Decision |
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2019-10-14 09:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-10-14 18:20 |
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Articles in Press |
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2019-10-14 18:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-25 22:13 |
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Typeset the Manuscript |
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2019-11-13 04:46 |
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Publish the Manuscript Online |
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2019-11-28 08:04 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Review |
| Article Title |
Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug induced adverse events
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Elena Genova, Federica Cavion, Marianna Lucafò, Luigina De Leo, Marco Pelin, Gabriele Stocco and Giuliana Decorti |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Italian Ministry of Health (IRCCS Burlo Garofolo) |
RC 7_2014, RC 10_2019 |
| progetto fondo di ricerca Ateneo, Università di Trieste |
FRA2018 |
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| Corresponding Author |
Gabriele Stocco, PhD, Assistant Professor, Department of Life Sciences, University of Trieste, via Fleming 22, Trieste 34127, Italy. stoccog@units.it |
| Key Words |
Induced pluripotent stem cells; Organoids; Adverse drug reactions; Intestinal toxicity; Hepatic toxicity; Pancreatic toxicity |
| Core Tip |
Adverse drug reactions (ADRs) are one of the major clinical problems, especially in pediatric patients, who may respond differently to drugs with respect to adults. This up-to-date review focuses on the employment of patient-derived induced pluripotent stem cells and related systems (i.e., stem cell-derived organoids) to study ADRs in the adult and, wherever available, in the pediatric field. We especially focused on the intestinal, hepatic, pancreatic, renal, cardiac and neuronal levels, in which the major ADRs are usually observed. Due to their genetic and physiological species-specific differences, these models may be accurate in predicting drug toxicity. |
| Publish Date |
2019-11-28 08:04 |
| Citation |
Genova E, Cavion F, Lucafò M, De Leo L, Pelin M, Stocco G, Decorti G. Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug induced adverse events. World J Stem Cells 2019; 11(12): 1020-1044 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i12/1020.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i12.1020 |
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