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11/28/2019 8:04:08 AM | Browse: 16 | Download: 12
Publication Name World Journal of Stem Cells
Manuscript ID 47741
Country of Manuscript Source China
Received
2019-03-26 01:27
Peer-Review Started
2019-03-28 09:10
To Make the First Decision
2019-04-16 07:48
Return for Revision
2019-05-13 03:10
Revised
2019-09-13 18:28
Second Decision
2019-10-14 08:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-14 18:08
Articles in Press
2019-10-14 18:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-11-13 05:43
Publish the Manuscript Online
2019-11-28 08:04
ISSN 1948-0210 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript Type Review
Article Title Small molecules for mesenchymal stem cell fate determination
Manuscript Source Invited Manuscript
All Author List Yu-Hao Cheng, Jing-Cheng Dong and Qin Bian
ORCID
Author(s) ORCID Number
Yu-Hao Cheng http://orcid.org/0000-0002-7472-8518
Jing-Cheng Dong http://orcid.org/0000-0002-3645-0324
Qin Bian http://orcid.org/0000-0003-4190-0913
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81573992
Corresponding author Qin Bian, MD, PhD, Professor, The Institutes of Integrative Medicine, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. qbian1@jhmi.edu
Keywords Mesenchymal stem cell; Mesenchymal stromal cell; Cell fate determination; Small molecules; Natural compounds; Signaling pathways
Core Tip Mesenchymal stem cells (MSCs), also called MSCs, are adult stem cells with multilineage differentiation potential. They serve crucial physiological roles, regulating the bone marrow microenvironment and adipose tissue remodeling in vivo. A complex regulatory network and signaling pathways are involved in governing MSC fate commitment. Much progress has been made in recent years in discovering small molecules and their underlying mechanisms that control the cell fate of MSCs. In this review, we summarize recent findings in applying small molecules to the trilineage cell fate commitment of MSCs, highlighting the underlying mechanisms and the current clinical trials. The small molecules for MSC fate determination offer substantial insights into bone marrow and adipose tissue homeostasis and therapeutic strategies for MSC-related diseases.
Publish Date 2019-11-28 08:04
Citation Cheng YH, Dong JC, Bian Q. Small molecules for mesenchymal stem cell fate determination. World J Stem Cells 2019; 11(12): 1084-1103
Url https://www.wjgnet.com/1948-0210/full/v11/i12/1084.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i12.1084
Full Article (PDF) WJSC-11-1084.pdf
Full Article (Word) WJSC-11-1084.docx
Manuscript File 47741-Review.docx
Answering Reviewers 47741-Answering reviewers.pdf
Audio Core Tip 47741-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47741-Conflict-of-interest statement.pdf
Copyright License Agreement 47741-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47741-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 47741-Language certificate.pdf
Peer-review Report 47741-Peer-review(s).pdf
Scientific Misconduct Check 47741-Scientific misconduct check.pdf
Scientific Editor Work List 47741-Scientific editor work list.pdf