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Articles Published Processes
9/7/2019 4:43:36 AM | Browse: 841 | Download: 1739
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Received |
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2019-03-25 05:32 |
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Peer-Review Started |
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2019-03-25 09:20 |
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To Make the First Decision |
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2019-05-27 01:06 |
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Return for Revision |
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2019-05-27 06:27 |
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Revised |
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2019-07-12 06:12 |
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Second Decision |
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2019-07-19 09:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-07-19 16:16 |
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Articles in Press |
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2019-07-19 16:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-08-10 19:01 |
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Typeset the Manuscript |
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2019-09-04 03:19 |
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Publish the Manuscript Online |
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2019-09-07 04:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marianne A De Roza, Lim Kai, Jiawen Kam, Yiong Huak Chan, Andrew Kwek, Tiing Leong Ang and John Chen Hsiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
John Chen Hsiang, MBChB, Attending Doctor, Doctor, Senior Researcher, Gastroenterology and Hepatology, Changi General Hospital, 2 Simei Street 3, Singhealth 529889, Singapore. jchsiang@gmail.com |
| Key Words |
Proton pump inhibitor; Liver cirrhosis; Mortality; Hospitalization; Complications; Portal hypertension |
| Core Tip |
Most proton pump inhibitor (PPI) studies have issues with poorly defining PPI users and having baseline confounders. Also, studies on PPI use in liver cirrhosis were not focused on decompensated cirrhosis. Using propensity score analysis, we adjusted for 43 variables including baseline characteristics, comorbidities, PPI indication, and medications (including antiplatelets). Landmark analysis was used to define PPI users to reduce bias. PPI use in patients with decompensated liver cirrhosis is associated with higher mortality and increased risk of hepatic decompensations requiring hospital admissions. Longer PPI exposure with > 90 defined daily doses further increased mortality risk. |
| Publish Date |
2019-09-07 04:43 |
| Citation |
De Roza MA, Lim K, Kam JW, Chan YH, Kwek A, Ang TL, Hsiang JC. Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis. World J Gastroenterol 2019;25(33): 4933-4944 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i33/4933.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i33.4933 |
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