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9/7/2019 4:43:36 AM | Browse: 20 | Download: 27
Publication Name World Journal of Gastroenterology
Manuscript ID 47780
Country of Manuscript Source Singapore
Received
2019-03-25 05:32
Peer-Review Started
2019-03-25 09:20
To Make the First Decision
2019-05-27 01:06
Return for Revision
2019-05-27 06:27
Revised
2019-07-12 06:12
Second Decision
2019-07-19 09:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-19 16:16
Articles in Press
2019-07-19 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-10 19:01
Typeset the Manuscript
2019-09-04 03:19
Publish the Manuscript Online
2019-09-07 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Cohort Study
Article Title Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Marianne A De Roza, Lim Kai, Jiawen Kam, Yiong Huak Chan, Andrew Kwek, Tiing Leong Ang and John Chen Hsiang
ORCID
Author(s) ORCID Number
Marianne A De Roza http://orcid.org/0000-0003-4247-8777
Lim Kai http://orcid.org/0000-0003-0941-6291
Jiawen Kam http://orcid.org/0000-0002-5201-7678
Yiong Huak Chan http://orcid.org/0000-0002-5076-5269
Andrew Kwek http://orcid.org/0000-0003-2870-8150
Tiing Leong Ang http://orcid.org/0000-0001-9993-8549
John Chen Hsiang http://orcid.org/0000-0002-7124-6396
Funding Agency and Grant Number
Correspondence To John Chen Hsiang, MBChB, Attending Doctor, Doctor, Senior Researcher, Gastroenterology and Hepatology, Changi General Hospital, 2 Simei Street 3, Singhealth 529889, Singapore. jchsiang@gmail.com
Keywords Proton pump inhibitor; Liver cirrhosis; Mortality; Hospitalization; Complications; Portal hypertension
Core Tip Most proton pump inhibitor (PPI) studies have issues with poorly defining PPI users and having baseline confounders. Also, studies on PPI use in liver cirrhosis were not focused on decompensated cirrhosis. Using propensity score analysis, we adjusted for 43 variables including baseline characteristics, comorbidities, PPI indication, and medications (including antiplatelets). Landmark analysis was used to define PPI users to reduce bias. PPI use in patients with decompensated liver cirrhosis is associated with higher mortality and increased risk of hepatic decompensations requiring hospital admissions. Longer PPI exposure with > 90 defined daily doses further increased mortality risk.
Publish Date 2019-09-07 04:43
Citation De Roza MA, Lim K, Kam JW, Chan YH, Kwek A, Ang TL, Hsiang JC. Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis. World J Gastroenterol 2019;25(33): 4933-4944
Url https://www.wjgnet.com/1007-9327/full/v25/i33/4933.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i33.4933
Full Article (PDF) WJG-25-4933.pdf
Full Article (Word) WJG-25-4933.docx
Manuscript File 47780-Review-PDF.pdf
Answering Reviewers 47780-Answering reviewers.pdf
Audio Core Tip 47780-Audio core tip.m4a
Biostatistics Review Certificate 47780-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47780-Conflict-of-interest statement.pdf
Copyright License Agreement 47780-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 47780-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47780-Institutional review board statement.pdf
Supplementary Material 47780-Supplementary material.pdf
Peer-review Report 47780-Peer-review(s).pdf
Scientific Misconduct Check 47780-Scientific misconduct check.pdf
Scientific Editor Work List 47780-Scientific editor work list.pdf