Publication Name	World Journal of Gastroenterology
Manuscript ID	4793
Country	Japan

Received	2013-07-24 10:50
Peer-Review Started	2013-07-24 14:58
To Make the First Decision
Return for Revision
Revised	2013-09-16 14:12
Second Decision	2013-09-16 17:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 06:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-08 19:56
Publish the Manuscript Online	2014-02-20 19:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding
Manuscript Source	Invited Manuscript
All Author List	Minoru Tomizawa, Fuminobu Shinozaki, Rumiko Hasegawa, Akira Togawa, Yoshinori Shirai, Noboru Ichiki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto and Makoto Sueishi
Funding Agency and Grant Number
Corresponding Author	Minoru Tomizawa, MD, PhD, Head, Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba 284-0003, Japan. nihminor-cib@umin.ac.jp
Key Words	Receiver operating characteristic; Area under curve; Sensitivity; Specificity; Gastrointestinal bleeding
Core Tip	Mortality rate of upper gastrointestinal (GI) bleeding is approximately 10%. Early upper gastrointestinal endoscopy significantly reduces mortality. We attempted to search for predictors of bleeding. Patient records were analyzed retrospectively. The rate of change was calculated as follows: (the result of blood examination on the day of endoscopy - the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. Predictors for upper GI bleeding were hemoglobin (Hb) < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the C-reactive protein > 100%, 3 mo before endoscopy.
Publish Date	2014-02-20 19:40
Citation	Tomizawa M, Shinozaki F, Hasegawa R, Togawa A, Shirai Y, Ichiki N, Motoyoshi Y, Sugiyama T, Yamamoto S, Sueishi M. Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding. World J Gastroenterol 2014; 20(5): 1311-1317
URL	http://www.wjgnet.com/1007-9327/full/v20/i5/1311.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i5.1311

Full Article (PDF)	WJG-20-1311.pdf
Full Article (Word)	WJG-20-1311.doc
Manuscript File	4793-Review.doc
Answering Reviewers	4793-Answering Reviewers.pdf
Copyright License Agreement	4793-Copyright Assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130723155442.tif
Non-Native Speakers of English Editing Certificate	4793-Language Certificate.pdf
Peer-review Report	4793-Peer review(s).pdf
Scientific Editor Work List	4793-Scientific editor work list.doc