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Articles Published Processes
7/28/2019 10:51:57 AM | Browse: 881 | Download: 1213
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Received |
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2019-04-06 07:45 |
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Peer-Review Started |
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2019-04-08 01:56 |
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To Make the First Decision |
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2019-05-31 00:30 |
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Return for Revision |
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2019-05-31 01:56 |
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Revised |
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2019-06-12 19:08 |
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Second Decision |
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2019-06-17 10:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-06-23 01:54 |
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Articles in Press |
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2019-06-23 01:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-03 21:40 |
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Typeset the Manuscript |
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2019-07-26 06:50 |
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Publish the Manuscript Online |
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2019-07-28 10:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Importance of fatigue and its measurement in chronic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lynn H Gerber, Ali A Weinstein, Rohini Mehta and Zobair M Younossi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lynn H Gerber, MD, Professor, Department of Medicine, Fairfax Medical Campus, Inova Health System, 3300 Gallows Rd, Falls Church, VA 22042, United States. ngerber1@gmu.edu |
| Key Words |
Fatigue; Chronic liver disease; Non-alcoholic fatty liver diseases; Non-alcoholic steatohepatitis; Measurement; Patient-reported outcomes |
| Core Tip |
Fatigue is prevalent, persistent and complex in people with non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). Fatigue can be analyzed in terms of peripheral and central fatigue, increasing precision of evaluation while elucidating causes and improving treatment. Liver is central to the pathogenesis of fatigue, which in our view, is dependent upon energy regulation. Biosignatures for fatigue are being tested that reflect metabolic and inflammatory pathways of relevance. Non-pharmacological treatments are effective in treating fatigue in NAFLD/NASH, including weight loss, aerobic and resistance exercise. Pharmacological agents, to date, have not been shown to have a significant/reliable effect in reducing fatigue. |
| Publish Date |
2019-07-28 10:51 |
| Citation |
Gerber LH, Weinstein AA, Mehta R, Younossi ZM. Importance of fatigue and its measurement in chronic liver disease. World J Gastroenterol 2019; 25(28): 3669-3683 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i28/3669.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i28.3669 |
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