Publication Name	World Journal of Gastroenterology
Manuscript ID	4842
Country	United States

Received	2013-07-26 11:26
Peer-Review Started	2013-07-26 13:43
To Make the First Decision	2013-08-21 18:38
Return for Revision	2013-08-22 19:23
Revised	2013-08-27 09:30
Second Decision	2013-09-03 14:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-04 07:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-01 08:41
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Mesenteric vein thrombosis in a patient heterozygous for factor Ⅴ Leiden and G20210A prothrombin genotypes
Manuscript Source	Invited Manuscript
All Author List	Paras Karmacharya, Madan Raj Aryal and Anthony Donato
Funding Agency and Grant Number
Corresponding Author	Paras Karmacharya, MD, Department of Internal Medicine, 6th avenue and Spruce Street, Reading Health System, West Reading, PA 19611, United States. paraskarmacharya@gmail.com
Key Words	Mesenteric vein thrombosis; Prothrombin gene; Factor V Leiden; Heterozygous; Anticoagulation; Oral contraceptives
Core Tip	The common presence of two thrombophilic defects increases the thrombotic risk several folds above the risk of a single defect and these tend to occur at an earlier age as seen in our case. Also the risk of recurrent thrombosis is significantly increased among these heterozygotes. Indefinite anticoagulation with oral anticoagulants (goal International Normalized Ratio = 2-3) is recommended for high risk patients like our case with thrombosis at unusual sites (e.g., mesenteric vein), and heterozygosity for both factor V Leiden and prothrombin G20210A mutations. These patients should avoid any hormonal therapy and family members should be screened for underlying prothrombotic condition.
Publish Date	2013-12-18 09:53
Citation	Karmacharya P, Aryal MR, Donato A. Mesenteric vein thrombosis in a patient heterozygous for factor Ⅴ Leiden and G20210A prothrombin genotypes. World J Gastroenterol 2013; 19(43): 7813-7815
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7813.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7813

Full Article (PDF)	WJG-19-7813.pdf
Manuscript File	4842-Review.docx
Answering Reviewers	4842-Answering reviewers.pdf
Copyright License Agreement	4842-Copyright assignment.pdf
Peer-review Report	4842-Peer review(s).pdf
Scientific Editor Work List	4842-Scientific editor work list.doc