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9/12/2014 8:41:00 PM | Browse: 1001 | Download: 1035
Publication Name World Journal of Gastroenterology
Manuscript ID 4853
Country/Territory Australia
Received
2013-07-28 06:33
Peer-Review Started
2013-07-29 17:24
To Make the First Decision
2013-08-21 18:36
Return for Revision
2013-08-22 19:29
Revised
Second Decision
2013-09-29 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-29 21:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-29 20:40
Publish the Manuscript Online
2013-11-16 18:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
Manuscript Source Invited Manuscript
All Author List Mohammed Eslam, David R Booth, Jacob George and Golo Ahlenstiel
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council Project APP1006759
Robert W. Storr bequest to the Sydney Medical Foundation of the University of Sydney to Ahlenstiel G and George J
International Postgraduate Research Scholarships to Eslam M
Australian Postgraduate Award of the University of Sydney to Eslam M
Corresponding Author Dr. Golo Ahlenstiel, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, NSW 2145, Australia. golo.ahlenstiel@sydney.edu.au
Key Words IFNL3; Chronic hepatitis C; Insulin resistance; Lipids
Core Tip Metabolic changes are inextricably linked to chronic hepatitis C (CHC). Recently polymorphisms in the IFNL3 region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus (HCV) infection. Further, circumstantial evidence suggests a link between IFNL3 single nucleotide polymorphisms and lipid metabolism, steatosis and insulin resistance in CHC. The emerging picture suggests that the responder genotypes of IFNL3 polymorphisms are associated with a higher serum lipid profile, and less frequent steatosis and insulin resistance. This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.
Publish Date 2013-11-16 18:29
Citation Eslam M, Booth DR, George J, Ahlenstiel G. Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection. World J Gastroenterol 2013; 19(41): 7055-7061
URL http://www.wjgnet.com/1007-9327/full/v19/i41/7055.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i41.7055
Full Article (PDF) WJG-19-7055.pdf
Manuscript File 4853-Review.docx
Answering Reviewers 4853-Answering reviewers.pdf
Biostatistics Review Certificate Biostatistician_Review_Report_20130727165057.pdf
Copyright License Agreement 4853-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20130727164909.pdf
Peer-review Report 4853-Peer review(s).pdf
Scientific Editor Work List 4853-Scientific editor work list.doc