Publication Name	World Journal of Experimental Medicine
Manuscript ID	4895
Country	United States

Received	2013-07-31 10:35
Peer-Review Started	2013-07-31 17:43
To Make the First Decision	2013-08-21 18:52
Return for Revision	2013-08-27 10:09
Revised	2013-09-27 22:45
Second Decision	2013-11-04 16:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-05 09:05
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-18 11:51
Publish the Manuscript Online	2013-11-20 17:44

ISSN	2220-315x (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	RNA vaccines for anti-tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Fabian Benencia
Funding Agency and Grant Number	Funding Agency Grant Number Ohio University and a Research Scholarly Affairs Committee grant award RP1206(to Benencia F)
Corresponding Author	Fabian Benencia, PhD, Assistant Professor of Immunology, Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Academic Research Center, Ohio University, 61 Oxbow Trail, Athens, OH 45701, United States. benencia@ohio.edu
Key Words	RNA; Vaccine; Dendritic cells; Immunization; Cytotoxic T cells; Tumors
Core Tip	In this review we discuss the use of RNA encoding tumor antigens for anti-tumor vaccination. RNA has several features that makes it relevant for vaccination purposes. Importantly, the RNA has no possibility of integration into the genome, and the tumor translated proteins enter the intrinsic antigen processing pathway thus enabling presentation by MHC-I molecules thus specifically activating cytotoxic CD8 T. Further, RNA can be delivered as a naked molecule f or can be used to transfect dendritic cells. This combination of RNA technology with dendritic cell vaccination provides a powerful tool for cancer immunotherapies.
Publish Date	2013-11-20 17:44
Citation	Benencia F. RNA vaccines for anti-tumor therapy. World J Exp Med 2013; 3(4): 62-73
URL	http://www.wjgnet.com/2220-315X/full/v3/i4/62.htm
DOI	http://dx.doi.org/10.5493/wjem.v3.i4.62

Full Article (PDF)	WJEM-3-62.pdf
Manuscript File	4895-Review.docx
Answering Reviewers	4895-Answering reviewers.pdf
Copyright License Agreement	4895-Copyright assignment.pdf
Peer-review Report	4895-Peer reviewer(s).pdf
Scientific Editor Work List	4895-Scientific editor work list.doc