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9/11/2014 8:39:00 PM | Browse: 495 | Download: 561
Publication Name World Journal of Gastroenterology
Manuscript ID 4896
Country/Territory China
Received
2013-07-31 10:42
Peer-Review Started
2013-07-31 23:26
To Make the First Decision
2013-08-21 18:52
Return for Revision
2013-08-30 11:01
Revised
2013-09-07 00:00
Second Decision
2013-11-04 18:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-05 10:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-11-19 11:15
Typeset the Manuscript
2013-12-10 12:10
Publish the Manuscript Online
2014-01-20 16:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Radiology, Nuclear Medicine and Medical Imaging
Manuscript Type Autobiography
Article Title Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats
Manuscript Source Invited Manuscript
All Author List Feng Chen, Frederik De Keyzer, Yuan-Bo Feng, Marlein Miranda Cona, Jie Yu, Guy Marchal, Raymond Oyen and Yi-Cheng Ni
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30670603
Corresponding author Feng Chen, MD, PhD, Deputy Director, Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. chenfengbe@aliyun.com
Key Words Diffusion weighted imaging; Magnetic resonance imaging; Therapeutic assessment; Liver tumor; Rats; Vascular disrupting agent; Antiangiogenic agent; Animal model; Rodents
Core Tip The combination therapy with ZD6126 and thalidomide significantly delayed liver tumor growth due to synergistic effects by inducing cumulative tumor necrosis in rodents. The apparent diffusion coefficient (ADC)high performed significantly better than ADCall for the monitoring of tumor necrosis on day 2. The ADCperf could better reflect the reduction of blood flow due to the vessel shutdown induced by ZD6126, compared to the ADClow. The ADCperf could provide valuable perfusion information from diffusion weighted magnetic resonance imaging data.
Publish Date 2014-01-20 16:41
Citation Chen F, Keyzer FD, Feng YB, Cona MM, Yu J, Marchal G, Oyen R, Ni YC. Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats. World J Gastroenterol 2013; 19(47): 9092-9103
Url http://www.wjgnet.com/1007-9327/full/v19/i47/9092.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i47.9092
Full Article (PDF) WJG-19-9092.pdf
Manuscript File 4896-Review.doc
Answering Reviewers 4896-Answering reviewers.pdf
Copyright License Agreement 4896-Copyright assignment.pdf
Peer-review Report 4896-Peer reviewer(s).pdf
Scientific Editor Work List 4896-Scientific editor work list.doc