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Articles Published Processes
9/7/2019 4:43:36 AM | Browse: 716 | Download: 993
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Received |
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2019-05-30 02:58 |
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Peer-Review Started |
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2019-05-30 06:40 |
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To Make the First Decision |
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2019-07-22 03:40 |
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Return for Revision |
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2019-07-23 02:17 |
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Revised |
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2019-07-30 07:48 |
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Second Decision |
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2019-08-02 10:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-08-07 09:30 |
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Articles in Press |
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2019-08-07 09:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-09-04 03:17 |
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Publish the Manuscript Online |
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2019-09-07 04:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Role of NLRP3 inflammasome in inflammatory bowel diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Evanthia Tourkochristou, Ioanna Aggeletopoulou, Christos Konstantakis and Christos Triantos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Christos Triantos, FAASLD, MD, PhD, Assistant Professor, Senior Scientist, Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, D. Stamatopoulou 4, Patras 26504, Greece. chtriantos@upatras.gr |
| Key Words |
NLRP3 inflammasome; Inflammatory bowel diseases; Mucosal immune system; Interleukin 1β; Interleukin 18; NLRP3 gene polymorphisms |
| Core Tip |
NLRP3 inflammasome plays a major role in inflammatory bowel diseases (IBD) pathogenesis through its contribution to chronic inflammatory processes. Abnormal activation of NLRP3 inflammasome has been observed in inflamed tissue of IBD murine models and patients, highlighting its possible pathogenic role in the disease. However, protective effects of NLRP3 function have also been recorded. The pathogenic NLRP3 inflammasome activity in mucosal immune system may be implicated in the aberrant immune responses and in the disruption of intestinal homeostasis that characterizes IBD. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies. |
| Publish Date |
2019-09-07 04:43 |
| Citation |
Tourkochristou E, Aggeletopoulou I, Konstantakis C, Triantos C. Role of NLRP3 inflammasome in inflammatory bowel diseases. World J Gastroenterol 2019; 25(33): 4796-4804 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i33/4796.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i33.4796 |
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