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9/4/2014 5:33:00 PM | Browse: 706 | Download: 680
Publication Name World Journal of Gastroenterology
Manuscript ID 4969
Country/Territory China
Received
2013-08-06 09:56
Peer-Review Started
2013-08-06 21:31
To Make the First Decision
2013-09-09 16:50
Return for Revision
2013-09-10 11:11
Revised
2013-10-08 15:45
Second Decision
2013-10-17 14:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-10-18 07:59
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-10-29 17:03
Typeset the Manuscript
2014-01-06 10:25
Publish the Manuscript Online
2014-01-20 17:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Autobiography
Article Title ALK gene copy number gain and its clinical significance in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Shou-Wei Jia, Sha Fu, Fang Wang, Qiong Shao, Hong-Bing Huang and Jian-Yong Shao
Funding Agency and Grant Number
Corresponding Author Jian-Yong Shao, MD, PhD, Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, No.651 Dongfeng Road, Guangzhou 510060, Guangdong Province, China. shaojy@sysucc.org.cn
Key Words Anaplastic lymphoma kinase gene; Hepatocellular carcinoma; Prognostic predictor
Core Tip This study retrospectively analyzed the status and clinical significance of anaplastic lymphoma kinase (ALK) gene alterations in a relatively large number of hepatocellular carcinoma (HCC) patients. We used HCC tissue microarrays to detect ALK transcripts by fluorescent in situ hybridization. No positive cases of ALK gene rearrangements and ALK amplification were observed. However, we found that ALK gene copy number gain (ALK/CNG) was common in HCC (13.15%, 28/213). Our findings suggest that ALK/CNG may serve as a prognostic marker for HCC, especially in patients with advanced stage, grade Ⅲ pathology.
Publish Date 2014-01-20 17:10
Citation Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY. ALK gene copy number gain and its clinical significance in hepatocellular carcinoma. World J Gastroenterol 2014; 20(1): 183-192
URL http://www.wjgnet.com/1007-9327/full/v20/i1/183.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i1.183
Full Article (PDF) WJG-20-183.pdf
Full Article (Word) WJG-20-183.doc
Manuscript File 4969-Review.doc
Answering Reviewers 4969-Answering reviewers.pdf
Copyright License Agreement 4969-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4969-Language certificate.pdf
Peer-review Report 4969-Peer reviews.pdf
Scientific Editor Work List 4969-Scientific editor work list.doc