| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong Do You, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Kyu-Seok Hwang, Sang Chul Lee, Kee-Hwan Kim, Ho Joong Choi, Ha-Eun Hong, Haeyeon Seo, Tae Ho Hong, Jung Hyun Park, Tae Yun Lee, Joseph Ahn, Jae-Kyung Jung, Kwan-Young Jung and Say-June Kim |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Catholic Medical Center Research Foundation |
program year of 2018 |
|
| Corresponding Author |
Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com |
| Key Words |
Tert-amyl ethyl ether; Gallstones; Methyl-tert-butyl ether; Contact litholytic agent; ; |
| Core Tip |
We developed a novel gallstone-dissolving agent, named tert-amyl ethyl ether (TAEE), an methyl-tertiary butyl ether (MTBE) analogue, with a relatively higher boiling point (102 °C). The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%, 56.5% and 38.75% for cholesterol, mixed, and pigmented gallstones, respectively, which represented a 1.2-, 1.4-, and 1.3-fold increase in dissolubility compared to that of MTBE. In the in vivo experiment, TAEE showed a 1.4- and 1.9-fold higher dissolubility for cholesterol and pigmented gallstones than MTBE. As such, TAEE could present an attractive alternative to MTBE if further clinical studies validate its efficacy and safety. |
| Publish Date |
2019-10-21 09:37 |
| Citation |
You DD, Cho SJ, Kim OH, Song JS, Hwang KS, Lee SC, Kim KH, Choi HJ, Hong HE, Seo H, Hong TH, Park JH, Lee TY, Ahn J, Jung JK, Jung KY, Kim SJ. Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether. World J Gastroenterol 2019; 25(39): 5936-5952 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i39/5936.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i39.5936 |
