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9/12/2014 8:41:00 PM | Browse: 987 | Download: 818
Publication Name World Journal of Gastroenterology
Manuscript ID 5048
Country/Territory United States
Received
2013-08-12 11:15
Peer-Review Started
2013-08-12 15:20
To Make the First Decision
2013-09-02 16:20
Return for Revision
2013-09-04 11:14
Revised
2013-09-11 01:41
Second Decision
2013-09-17 09:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-17 11:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-15 17:18
Publish the Manuscript Online
2013-11-13 08:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics & Heredity
Manuscript Type Topic Highlights
Article Title Impact of exome sequencing in inflammatory bowel disease
Manuscript Source Invited Manuscript
All Author List Christopher J Cardinale, Judith R Kelsen, Robert N Baldassano and Hakon Hakonarson
Funding Agency and Grant Number
Funding Agency Grant Number
Senior Research Award from the Crohn’s to Cardinale CJ
Colitis Foundation of America to Hakonarson H
special purpose fund from the Edmunds Family Foundation for Ulcerative Colitis Studies to Baldassano RN
Corresponding Author Hakon Hakonarson, MD, PhD, Director, Center for Applied Genomics, Children's Hospital of Philadelphia, Abramson Research Center Suite 1216, 3615 Civic Center Blvd, Philadelphia, PA 19104, United States. hakonarson@chop.edu
Key Words Sequencing; Exome; Genetics; Inflammatory bowel disease
Core Tip The genetic understanding of inflammatory bowel disease (IBD) has progressed over the last twenty years as new technologies and analytic techniques have become available. The nascent revolution in next-generation sequencing will enable us to sequence the exome - all the protein coding genes in the genome - in thousands of individuals. This review discusses the implications of this new approach for diagnosis in very early onset IBD and as a tool to gain understanding of the hereditary basis of the common polygenic form of the disease at the population level.
Publish Date 2013-11-13 08:37
Citation Cardinale CJ, Kelsen JR, Baldassano RN, Hakonarson H. Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol 2013; 19(40): 6721-6729
URL http://www.wjgnet.com/1007-9327/full/v19/i40/6721.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i40.6721
Full Article (PDF) WJG-19-6721.pdf
Manuscript File 5048-Review.docx
Answering Reviewers 5048-Answering reviewers.pdf
Copyright License Agreement 5048-Copyright assignment.pdf
Peer-review Report 5048-Peer reviews.pdf
Scientific Editor Work List 5048-Scientific editor work list.doc