Publication Name	World Journal of Gastroenterology
Manuscript ID	5052
Country	Germany

Received	2013-08-12 11:40
Peer-Review Started	2013-08-12 16:41
To Make the First Decision	2013-09-02 16:20
Return for Revision	2013-09-05 14:41
Revised	2013-09-05 23:58
Second Decision	2013-09-17 09:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 11:45
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-18 11:50
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Extravascular use of drug-eluting beads: A promising approach in compartment-based tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Simon Binder, Andrew L Lewis, J-Matthias Löhr and Michael Keese
Funding Agency and Grant Number
Corresponding Author	Michael Keese, PD, MD, Clinic for Vascular and Endovascular Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. michael.keese@kgu.de
Key Words	Compartment based therapy; Intraperitoneal; Drug-eluting beads; Carcinomatosis; Hyperthermic intraperitoneal chemotherapy; Glioblastoma; Pancreatic cancer; CYP2B1; Ifosfamide
Core Tip	Intraperitoneal carcinomatosis occurs with several tumor entities and prognosis is usually poor. Besides standard therapy, only few patients may benefit from hyperthermic intraperitoneal chemotherapy. The treatment may cause severe systemic side-effects. One different approach to target chemotherapeutic agents to the tumor employs carrier devices. Contemplable carriers are drug-eluting beads (DEBs). DEBs can be used to transfer drugs or pro-drug converting enzymes directly to the tumor. Furthermore, DEBs can successfully target chemotherapeutics into the abdominal cavity for ip treatment. When local toxic effects are controlled, DEBs are effective tools in compartment-based therapy.
Publish Date	2013-12-18 09:53
Citation	Binder S, Lewis AL, L?hr JM, Keese M. Extravascular use of drug-eluting beads: A promising approach in compartment-based tumor therapy. World J Gastroenterol 2013; 19(43): 7586-7593
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7586.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7586

Full Article (PDF)	WJG-19-7586.pdf
Manuscript File	5052-Review.doc
Answering Reviewers	5052-Answering reviewers.pdf
Copyright License Agreement	5052-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5052-Language certificate.pdf
Peer-review Report	5052-Peer reviews.pdf
Scientific Editor Work List	5052-Scientific editor work list.doc