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Publication Name World Journal of Transplantation
Manuscript ID 51316
Country/Territory United States
2019-09-08 20:13
Peer-Review Started
2019-09-08 20:13
To Make the First Decision
2019-10-15 00:28
Return for Revision
2019-10-15 01:44
2019-10-26 02:19
Second Decision
2019-12-06 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-12-06 19:11
Articles in Press
2019-12-06 19:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-01-10 02:17
Publish the Manuscript Online
2020-01-14 10:51
ISSN 2220-3230 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Review
Article Title Therapeutics administered during ex vivo liver machine perfusion: An overview
Manuscript Source Invited Manuscript
All Author List Julianna E Buchwald, Jing Xu, Adel Bozorgzadeh and Paulo N Martins
Author(s) ORCID Number
Julianna E Buchwald http://orcid.org/0000-0001-5893-471X
Jing Xu http://orcid.org/0000-0001-9391-6146
Adel Bozorgzadeh http://orcid.org/0000-0002-0790-9562
Paulo N Martins http://orcid.org/0000-0001-9333-0233
Funding Agency and Grant Number
Corresponding author Paulo N Martins, MD, PhD, Assistant Professor, Attending Doctor, Surgeon, Department of Surgery, Transplant Division, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, United States. paulo.martins@umassmemorial.org
Keywords Therapeutics; Liver transplantation; Ex vivo machine perfusion; Ischemia reperfusion injury; Organ preservation; Extended criteria donors
Core Tip The use of extended criteria donors has increased the donor pool of available livers for transplant but has also introduced other hurdles in protecting these vulnerable organs against ischemia-reperfusion injury (IRI). Current basic science research is aimed at mitigating the effects of IRI during the transplantation process by administering therapeutics during ex vivo liver machine perfusion. Of interest include therapeutics aimed at evoking the RNA interference pathway, utilizing defatting cocktails, and administering classes of agents such as vasodilators and anti-inflammatory drugs to reduce the damage of IRI following liver procurement and transplantation for ultimate preservation of the organ.
Publish Date 2020-01-14 10:51
Citation Buchwald JE, Xu J, Bozorgzadeh A, Martins PN. Therapeutics administered during ex vivo liver machine perfusion: An overview. World J Transplant 2020; 10(1): 1-14
Url https://www.wjgnet.com/2220-3230/full/v10/i1/1.htm
DOI https://dx.doi.org/10.5500/wjt.v10.i1.1
Full Article (PDF) WJT-10-1.pdf
Full Article (Word) WJT-10-1.docx
Manuscript File 51316-Review.docx
Answering Reviewers 51316-Answering reviewers.pdf
Audio Core Tip 51316-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 51316-Conflict-of-interest statement.pdf
Copyright License Agreement 51316-Copyright license agreement.pdf
Peer-review Report 51316-Peer-review(s).pdf
Scientific Misconduct Check 51316-Scientific misconduct check.pdf
Scientific Editor Work List 51316-Scientific editor work list.pdf